Crygb^Clapper
Chemically induced Allele Detail

Summary

• Symbol: Crygb^Clapper
• Name: crystallin, gamma B; Clapper
• MGI ID: MGI:3590646
• Synonyms: gammaB-I4F, L10
• Gene: Crygb Location: Chr1:65119381-65121449 bp, - strand Genetic Position: Chr1, 32.82 cM
• Alliance: Crygb^Clapper page

Cataracts in Crygb^Clapper/Crygb^Clapper and Crygb^Clapper/Crygb⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This allele contains an A to T missense mutation that replaces the conserved fourth isoleucine residue with a phenylalanine. (J:100851)
• Inheritance: Dominant

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crygb Mutation: 15 strains or lines available

References

• Original: J:100851 Liu H, et al., Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency. J Biol Chem. 2005 Jul 1;280(26):25071-8
• All: 2 reference(s)