Apoa2 MGI Mouse Gene Detail - MGI:88050

Symbol

Apoa2
Name

apolipoprotein A-II
Synonyms

Alp-2, Apoa-2, ApoA-II, Hdl-1

Feature Type

protein coding gene
IDs

MGI:88050
NCBI Gene: 11807
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:171052623-171053948 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.22 cM
Mapping Data

77 experiments

SNPs within 2kb

110 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

11

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88050	protein coding gene	Chr1:171049133-171053948 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016747	protein coding gene	Chr1:177005836-177007160 (+)
A/J	MGP_AJ_G0016727	protein coding gene	Chr1:169806490-169807817 (+)
AKR/J	MGP_AKRJ_G0016693	protein coding gene	Chr1:174892267-174893592 (+)
BALB/cJ	MGP_BALBcJ_G0016688	protein coding gene	Chr1:170288996-170290320 (+)
C3H/HeJ	MGP_C3HHeJ_G0016511	protein coding gene	Chr1:175137087-175138411 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017149	protein coding gene	Chr1:182889449-182890774 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014857	protein coding gene	Chr1:161486859-161488164 (+)
CAST/EiJ	MGP_CASTEiJ_G0016092	protein coding gene	Chr1:174761338-174762663 (+)
CBA/J	MGP_CBAJ_G0016486	protein coding gene	Chr1:189404691-189406010 (+)
DBA/2J	MGP_DBA2J_G0016593	protein coding gene	Chr1:168645504-168646823 (+)
FVB/NJ	MGP_FVBNJ_G0016589	protein coding gene	Chr1:166994363-166995687 (+)
LP/J	MGP_LPJ_G0016664	protein coding gene	Chr1:178126940-178128264 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016616	protein coding gene	Chr1:196688166-196689486 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017186	protein coding gene	Chr1:174763228-174764555 (+)
PWK/PhJ	MGP_PWKPhJ_G0015878	protein coding gene	Chr1:167868472-167869800 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015662	protein coding gene	Chr1:173547578-173548899 (+)
WSB/EiJ	MGP_WSBEiJ_G0016154	protein coding gene	Chr1:174881658-174883023 (+)

Human Ortholog

APOA2, apolipoprotein A2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APOA2, apolipoprotein A2
Synonyms

apoAII, Apo-AII, ApoA-II
Links

HGNC:601

NCBI Gene ID: 336

neXtProt AC: NX_P02652

UniProt: P02652
Chr Location

1q23.3; chr1:161222293-161223628 (-) GRCh38.p7

Alliance of Genome Resources

Apoa2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: APOA2
Gene Tree

Apoa2

Diseases

1 with human APOA2 associations

				Human Disease	Mouse Models
				familial hypercholesterolemia IDs familial hypercholesterolemia DOID:13810 ICD10CM:E78.01 MESH:D006938 NCI:C34704 OMIM:143890 ORDO:406 UMLS_CUI:C0020445

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 5 alleles in 7 genetic backgrounds
10 phenotypes from multigenic genotypes
43 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

6
Targeted

6
Transgenic

2
Genomic Mutations

2 involving Apoa2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutation of this gene results in a reduction of total cholesterol, HDL cholesterol, free fatty acids, insulin, and glucose levels in both the fasted and unfasted states. Strain specific alleles have been associated with varying degrees of amyloidosis.

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All GO Annotations

81
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

865
Tissues

103
cDNA Data

429
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Apoa2 interacts with 6 markers (Mir93, Mir194-2, Mir325, ...) View All

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All Sequences

54
RefSeq

9
UniProt

2
CCDS

CCDS35773.1

Ensembl

ENSMUSG00000005681 (Evidence)
NCBI Gene

11807

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005681	Ensembl Gene Model \| MGI Sequence Detail	1326	C57BL/6J	± kb
transcript	ENSMUST00000111319	Ensembl \| MGI Sequence Detail	458	Not Applicable
polypeptide	ENSMUSP00000106951	Ensembl \| MGI Sequence Detail	102	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004142 apolipoprotein A-II

(term hierarchy)
InterPro Domains

IPR006801 Apolipoprotein A-II (ApoA-II)

IPR036172 Apolipoprotein A-II (ApoA-II) superfamily

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All nucleic 442

Genomic 5

cDNA 431

Primer pair 4

Other 2

Microarray probesets 3

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MGD-MRK-10688, MGD-MRK-1289, MGD-MRK-1365, MGD-MRK-1368

Summaries

All 158

Developmental Gene Expression 13

Gene Ontology 15

Phenotypes 43
Earliest

J:7017 Lusis AJ, et al., Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins. J Biol Chem. 1983 Apr 25;258(8):5071-8
Latest

J:322813 Cui X, et al., Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway. Dis Model Mech. 2022 Mar 1;15(3):dmm049327

TSS for Apoa2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9986	Chr1:171052646-171052669 (+)	35 bp
Tssr9987	Chr1:171052839-171052901 (+)	247 bp
Tssr9988	Chr1:171053231-171053279 (+)	632 bp
Tssr9989	Chr1:171053280-171053320 (+)	677 bp
Tssr9990	Chr1:171053322-171053336 (+)	706 bp
Tssr9991	Chr1:171053729-171053751 (+)	1,117 bp
Tssr9992	Chr1:171053842-171053866 (+)	1,231 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/31/2023 MGI 6.22