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Chrna4 Gene Detail
Summary
  • Symbol
    Chrna4
  • Name
    cholinergic receptor, nicotinic, alpha polypeptide 4
  • Synonyms
    a4 nicotinic receptor, Acra4, Acra-4, alpha4 nAChR, alpha4-nAChR
  • Feature Type
    protein coding gene
  • IDs
    MGI:87888
    NCBI Gene: 11438
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180664104-180685365 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 103.54 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87888
 protein coding gene Chr2:180660173-180685365 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027009
 protein coding gene Chr2:187588406-187613579 (-)
A/J MGP_AJ_G0026975
 protein coding gene Chr2:179872008-179897692 (-)
AKR/J MGP_AKRJ_G0026945
 protein coding gene Chr2:185263207-185288463 (-)
BALB/cJ MGP_BALBcJ_G0026984
 protein coding gene Chr2:180333059-180359533 (-)
C3H/HeJ MGP_C3HHeJ_G0026725
 protein coding gene Chr2:185620765-185645994 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027430
 protein coding gene Chr2:193012457-193038747 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024795
 protein coding gene Chr2:170557569-170577191 (-)
CAST/EiJ MGP_CASTEiJ_G0026184
 protein coding gene Chr2:183869285-183896214 (-)
CBA/J MGP_CBAJ_G0026702
 protein coding gene Chr2:200005901-200033113 (-)
DBA/2J MGP_DBA2J_G0026840
 protein coding gene Chr2:178964325-178989776 (-)
FVB/NJ MGP_FVBNJ_G0026806
 protein coding gene Chr2:177581239-177606405 (-)
LP/J MGP_LPJ_G0026941
 protein coding gene Chr2:187602698-187628050 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026825
 protein coding gene Chr2:202581666-202606848 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027489
 protein coding gene Chr2:185235081-185260256 (-)
PWK/PhJ MGP_PWKPhJ_G0025920
 protein coding gene Chr2:176489791-176515052 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025720
 protein coding gene Chr2:181713975-181744819 (-)
WSB/EiJ MGP_WSBEiJ_G0026256
 protein coding gene Chr2:186220372-186245172 (-)



Homology
more
  • Human Ortholog
    CHRNA4, cholinergic receptor nicotinic alpha 4 subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRNA4, cholinergic receptor nicotinic alpha 4 subunit
  • Synonyms
    BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
  • Links
    NCBI Gene ID: 1137
    neXtProt AC: NX_P43681
    UniProt: P43681

  • Chr Location
    20q13.33; chr20:63343310-63375392 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with human CHRNA4 associations

Human Disease Mouse Models
      
IDs
 View 1 "NOT" model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 10 alleles in 10 genetic backgrounds
    1 phenotype from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice may show reduced chemically-elicited analgesia, susceptibility to seizures, increased anxiety, and altered behavioral responses to nicotine or a new environment. Homozygotes for any of several knock-in alleles exhibit altered nervous system physiology and/or sensitivity to nicotine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    95
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    936
  • Tissues
    132
  • cDNA Data
    49
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11438 NCBI Gene Model | MGI Sequence Detail 21262 C57BL/6J ±  kb
    transcript NM_015730 RefSeq | MGI Sequence Detail 4509 C57BL/6  
    polypeptide O70174 UniProt | EBI | MGI Sequence Detail 629 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005457 neuronal acetylcholine receptor subunit alpha-4
      (term hierarchy)
    • InterPro Domains
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 52
      Primer pair 3
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1057, MGD-MRK-1061
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 12
      Diseases 3
      Gene Ontology 26
      Phenotypes 60
    • Earliest
      J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
    • Latest
      J:304657 Dezfuli G, et al., alpha4beta2 nicotinic acetylcholine receptors intrinsically influence body weight in mice. Neuropharmacology. 2020 Apr;166:107921
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    01/24/2023
    MGI 6.22     		The Jackson Laboratory