Slc17a8 MGI Mouse Gene Detail - MGI:3039629 - solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

Symbol

Slc17a8
Name

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
Synonyms

Vglut3, Vgt3

Feature Type

protein coding gene
IDs

MGI:3039629
NCBI Gene: 216227
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:89409882-89457111 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 44.99 cM
Mapping Data

1 experiment

SNPs within 2kb

1736 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3039629	protein coding gene	Chr10:89409882-89457115 (-)
129S1/SvImJ	ENSMUSG00200025804	protein coding gene	Chr10:85907828-85955086 (-)
A/J	ENSMUSG00195020120	protein coding gene	Chr10:86355105-86405190 (-)
AKR/J	ENSMUSG00220020705	protein coding gene	Chr10:85913742-85963824 (-)
BALB/cJ	ENSMUSG00180032232	protein coding gene	Chr10:86358049-86408128 (-)
C3H/HeJ	ENSMUSG00175022525	protein coding gene	Chr10:86241146-86288403 (-)
C57BL/6NJ	ENSMUSG00215017675	protein coding gene	Chr10:85910556-85957829 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015718	protein coding gene	Chr10:83371902-83419586 (-)
CAST/EiJ	ENSTCUG00005033158	protein coding gene	Chr10:85635617-85683193 (-)
CBA/J	ENSMUSG00210030005	protein coding gene	Chr10:86081595-86128860 (-)
DBA/2J	ENSMUSG00185039629	protein coding gene	Chr10:86302589-86349824 (-)
FVB/NJ	ENSMUSG00205013575	protein coding gene	Chr10:85960048-86010126 (-)
JF1/MsJ	ENSUMUG00000018425	protein coding gene	Chr10:87662021-87709306 (-)
LP/J	ENSMUSG00230013147	protein coding gene	Chr10:88188689-88235217 (-)
NOD/ShiLtJ	ENSMUSG00190017445	protein coding gene	Chr10:86340157-86390235 (-)
NZO/HlLtJ	ENSMUSG00225020599	protein coding gene	Chr10:92463556-92513625 (-)
PWK/PhJ	ENSLUMG00010022690	protein coding gene	Chr10:85968500-86015612 (-)
SPRET/EiJ	ENSMSPG00010030682	protein coding gene	Chr10:87486865-87528630 (-)
WSB/EiJ	ENSIUOG00005032591	protein coding gene	Chr10:86047167-86097559 (-)

Human Ortholog

SLC17A8, solute carrier family 17 member 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC17A8, solute carrier family 17 member 8
Synonyms

DFNA25, VGLUT3
Links

HGNC:20151

NCBI Gene ID: 246213

UniProt: Q8NDX2
Chr Location

12q23.1; chr12:100356842-100422055 (+) GRCh38

MGI Vertebrate Homology

Slc17a8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC17A8
Gene Tree

Slc17a8

Diseases

1 with Slc17a8 mouse models; 1 with human SLC17A8 associations

Human Disease

Mouse Models

autosomal dominant nonsyndromic deafness 25

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

34 phenotypes from 3 alleles in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
124 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Endonuclease-mediated

9
Targeted

11
Transposon induced

1
Genomic Mutations

2 involving Slc17a8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele exhibit sensorineural hearing loss, cochlear ganglion degeneration, decreased synaptic glutamate release, and nonconvulsive seizures.

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All GO Annotations

76
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

38
cDNA Data

7
Literature Summary

36

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN slc17a8

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All Sequences

36
RefSeq

4
UniProt

3
CCDS

CCDS24117.1, CCDS78880.1

Ensembl

ENSMUSG00000019935 (Evidence)
NCBI Gene

216227

			Length	Strain/Species	Flank
genomic	216227	NCBI Gene Model \| MGI Sequence Detail	47230	C57BL/6J	± kb
transcript	NM_182959	RefSeq \| MGI Sequence Detail	4452	C57BL/6
polypeptide	Q8BFU8	UniProt \| EBI \| MGI Sequence Detail	601	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014964 vesicular glutamate transporter 3

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR050382 Vesicular glutamate transporter-like
GlyGen

Q8BFU8 3 sites, 1 O-linked glycan (2 sites)

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All nucleic 8

cDNA 7

Primer pair 1

Antibodies 3

Microarray probesets 1

Summaries

All 218

Developmental Gene Expression 36

Diseases 1

Gene Ontology 15

Phenotypes 124
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:389708 Mukhopadhyay M, et al., Persistence of vestibular function in the absence of glutamatergic transmission from hair cells. Sci Rep. 2026 Mar 23;16(1)

TSS for Slc17a8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98884	Chr10:89457291-89457326 (-)	-198 bp
Tssr98883	Chr10:89457141-89457152 (-)	-36 bp
Tssr98882	Chr10:89457125-89457137 (-)	-20 bp
Tssr98881	Chr10:89457081-89457099 (-)	21 bp
Tssr98880	Chr10:89436554-89436581 (-)	20,543 bp
Tssr98879	Chr10:89428788-89428814 (-)	28,310 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24