Slc17a8^tm1Selm
Targeted Allele Detail

Summary

• Symbol: Slc17a8^tm1Selm
• Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8; targeted mutation 1, Salah El Mestikawy
• MGI ID: MGI:3794893
• Synonyms: Vglut3^-
• Gene: Slc17a8 Location: Chr10:89409882-89457111 bp, - strand Genetic Position: Chr10, 44.99 cM
• Alliance: Slc17a8^tm1Selm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135586
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with an frt-flanked neo cassette, which is read through during transcription. This results in creation of a stop codon in exon3. The absence of protein product was confirmed by immunohistochemistry on brain sections. (J:135586, J:139493)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc17a8 Mutation: 40 strains or lines available

References

• Original: J:135586 Gras C, et al., The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone. Nat Neurosci. 2008 Mar;11(3):292-300
• All: 13 reference(s)