Gpr161 MGI Mouse Gene Detail - MGI:2685054 - G protein-coupled receptor 161

Symbol

Gpr161
Name

G protein-coupled receptor 161
Synonyms

LOC240888, vl

Feature Type

protein coding gene
IDs

MGI:2685054
NCBI Gene: 240888
Alliance

genome feature page

Sequence Map

Chr1:165123358-165154314 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 72.64 cM
Mapping Data

4 experiments

SNPs within 2kb

1003 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685054	protein coding gene	Chr1:165108760-165154314 (+)
129S1/SvImJ	ENSMUSG00200005343	protein coding gene	Chr1:162623812-162654816 (+)
A/J	ENSMUSG00195018788	protein coding gene	Chr1:161928392-161959390 (+)
AKR/J	ENSMUSG00220013205	protein coding gene	Chr1:161717012-161748029 (+)
BALB/cJ	ENSMUSG00180036056	protein coding gene	Chr1:162177800-162208806 (+)
C3H/HeJ	ENSMUSG00175040889	protein coding gene	Chr1:162273561-162304588 (+)
C57BL/6NJ	ENSMUSG00215016662	protein coding gene	Chr1:162145635-162176592 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014803	protein coding gene	Chr1:155704655-155744746 (+)
CAST/EiJ	ENSTCUG00005019962	protein coding gene	Chr1:160719113-160750881 (+)
CBA/J	ENSMUSG00210021203	protein coding gene	Chr1:162148113-162179130 (+)
DBA/2J	ENSMUSG00185010626	protein coding gene	Chr1:166395022-166426929 (+)
FVB/NJ	ENSMUSG00205008196	protein coding gene	Chr1:161191797-161222761 (+)
JF1/MsJ	ENSUMUG00000007499	protein coding gene	Chr1:165545899-165577795 (+)
LP/J	ENSMUSG00230020998	protein coding gene	Chr1:166012935-166043924 (+)
NOD/ShiLtJ	ENSMUSG00190035676	protein coding gene	Chr1:161975279-162006255 (+)
NZO/HlLtJ	ENSMUSG00225004387	protein coding gene	Chr1:169598519-169629522 (+)
PWK/PhJ	ENSLUMG00010040898	protein coding gene	Chr1:160931931-160963843 (+)
SPRET/EiJ	ENSMSPG00010043575	protein coding gene	Chr1:164417189-164450304 (+)
WSB/EiJ	ENSIUOG00005014954	protein coding gene	Chr1:161472989-161503955 (+)

Human Ortholog

GPR161, G protein-coupled receptor 161

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR161, G protein-coupled receptor 161
Synonyms

RE2
Links

HGNC:23694

NCBI Gene ID: 23432

UniProt: Q8N6U8
Chr Location

1q24.2; chr1:168079542-168137685 (-) GRCh38

MGI Vertebrate Homology

Gpr161 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GPR161
Gene Tree

Gpr161

Diseases

1 with human GPR161 associations

				Human Disease	Mouse Models
				medulloblastoma IDs medulloblastoma DOID:0050902 DOID:0060105 DOID:168 DOID:3858 DOID:4981 MESH:D008527 MESH:D018242 NCI:C27294 NCI:C3222 NCI:C3716 OMIM:155255 ORDO:616 UMLS_CUI:C0025149 UMLS_CUI:C0206663 UMLS_CUI:C1334410

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

48 phenotypes from 3 alleles in 6 genetic backgrounds
8 phenotypes from multigenic genotypes
1 images
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

2
Endonuclease-mediated

3
Spontaneous

1
Targeted

10
Genomic Mutations

2 involving Gpr161
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display complete embryonic lethality during organogenesis, extensive craniofacial abnormalities, ventralization of the neural tube with expansion of the floor plate, absence of limb development, and caudal spina bifida.

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All GO Annotations

36
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

669
Tissues

47
cDNA Data

7
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpr161

ZFIN gpr161a, gpr161b

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All Sequences

50
RefSeq

14
UniProt

2
CCDS

CCDS78732.1, CCDS83621.1

Ensembl

ENSMUSG00000040836 (Evidence)
NCBI Gene

240888

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040836	Ensembl Gene Model \| MGI Sequence Detail	30957	C57BL/6J	± kb
transcript	ENSMUST00000178700	Ensembl \| MGI Sequence Detail	1827	Not Applicable
polypeptide	ENSMUSP00000136621	Ensembl \| MGI Sequence Detail	545	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001517 G-protein coupled receptor 161

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

B2RPY5 3 sites

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All nucleic 12

cDNA 7

Primer pair 4

Other 1

Antibodies 2

Microarray probesets 2

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MGD-MRK-15400, MGI:98934

Summaries

All 67

Developmental Gene Expression 14

Gene Ontology 14

Phenotypes 28
Earliest

J:133308 Wilson DB, et al., Closure of the posterior neuropore in the vl mutant mouse. Anat Embryol (Berl). 1988;178(6):559-63
Latest

J:385504 Krantz S, et al., Dissection of Galphas and Hedgehog Signaling Cross-talk Reveals Therapeutic Opportunities to Target Hedgehog-Dependent Tumors. Cancer Res. 2026 Feb 16;86(4):940-953

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24