Gpr75 MGI Mouse Gene Detail - MGI:2441843 - G protein-coupled receptor 75

Symbol

Gpr75
Name

G protein-coupled receptor 75

Feature Type

protein coding gene
IDs

MGI:2441843
NCBI Gene: 237716
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:30835358-30843729 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 18.16 cM
Mapping Data

1 experiment

SNPs within 2kb

245 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441843	protein coding gene	Chr11:30834636-30846090 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018117	protein coding gene	Chr11:29000776-29009773 (+)
A/J	MGP_AJ_G0018090	protein coding gene	Chr11:27919597-27927712 (+)
AKR/J	MGP_AKRJ_G0018054	protein coding gene	Chr11:28804792-28815158 (+)
BALB/cJ	MGP_BALBcJ_G0018059	protein coding gene	Chr11:28124258-28132313 (+)
C3H/HeJ	MGP_C3HHeJ_G0017872	protein coding gene	Chr11:28739703-28748611 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018510	protein coding gene	Chr11:29958879-29968189 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016167	protein coding gene	Chr11:26439082-26447217 (+)
CAST/EiJ	MGP_CASTEiJ_G0017434	protein coding gene	Chr11:28828283-28836333 (+)
CBA/J	MGP_CBAJ_G0017845	protein coding gene	Chr11:31402382-31414350 (+)
DBA/2J	MGP_DBA2J_G0017955	protein coding gene	Chr11:27736833-27745063 (+)
FVB/NJ	MGP_FVBNJ_G0017949	protein coding gene	Chr11:27531236-27539144 (+)
LP/J	MGP_LPJ_G0018027	protein coding gene	Chr11:29244756-29252963 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017973	protein coding gene	Chr11:32460114-32468453 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018551	protein coding gene	Chr11:28903169-28913382 (+)
PWK/PhJ	MGP_PWKPhJ_G0017216	protein coding gene	Chr11:27836164-27844760 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017010	protein coding gene	Chr11:28616981-28625092 (+)
WSB/EiJ	MGP_WSBEiJ_G0017486	protein coding gene	Chr11:28591655-28601316 (+)

Human Ortholog

GPR75, G protein-coupled receptor 75

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR75, G protein-coupled receptor 75
Synonyms

GPRchr2, WI31133
Links

HGNC:4526

NCBI Gene ID: 10936

neXtProt AC: NX_O95800

UniProt: O95800
Chr Location

2p16.2; chr2:53852912-53859967 (-) GRCh38

MGI Vertebrate Homology

Gpr75 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR75
Gene Tree

Gpr75

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

10
Targeted

2
Genomic Mutations

1 involving Gpr75
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit a mild progressive retinal degeneration caused by loss of both M-cone and S-cone photoreceptor cells that is accompanied by oxidative stress. Another null allele shows increased anxiety-like behaviors and disrupted fear conditioning recall. Males are resistant age-related gain in body mass.

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

61
cDNA Data

5
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpr75

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All Sequences

35
RefSeq

4
UniProt

2
CCDS

CCDS24508.1

Ensembl

ENSMUSG00000043999 (Evidence)
NCBI Gene

237716

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043999	Ensembl Gene Model \| MGI Sequence Detail	8372	C57BL/6J	± kb
transcript	ENSMUST00000109430	Ensembl \| MGI Sequence Detail	2926	Not Applicable
polypeptide	ENSMUSP00000105057	Ensembl \| MGI Sequence Detail	540	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001537 probable G-protein coupled receptor 75

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q6X632 3 sites

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All nucleic 7

cDNA 5

Primer pair 2

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:358547 Jiang Y, et al., Central regulation of feeding and body weight by ciliary GPR75. J Clin Invest. 2024 Aug 13;134(19)

TSS for Gpr75:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100762	Chr11:30833730-30833737 (+)	-1,624 bp
Tssr100763	Chr11:30835400-30835430 (+)	57 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24