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Rtn4r Gene Detail
Summary
  • Symbol
    Rtn4r
  • Name
    reticulon 4 receptor
  • Synonyms
    NgR, NgR1, Nogo-66 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136886
    NCBI Gene: 65079
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17945506-17970272 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.23 cM, cytoband B1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136886
protein coding gene Chr16:17945506-17970272 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022602
protein coding gene Chr16:15332654-15358980 (+)
A/J MGP_AJ_G0022563
protein coding gene Chr16:14568729-14594258 (+)
AKR/J MGP_AKRJ_G0022540
protein coding gene Chr16:15140466-15167304 (+)
BALB/cJ MGP_BALBcJ_G0022568
protein coding gene Chr16:14718563-14743693 (+)
C3H/HeJ MGP_C3HHeJ_G0022335
protein coding gene Chr16:15308299-15335250 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023017
protein coding gene Chr16:15593188-15624101 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020537
protein coding gene Chr16:14623200-14648154 (+)
CAST/EiJ MGP_CASTEiJ_G0021862
protein coding gene Chr16:15191208-15217881 (+)
CBA/J MGP_CBAJ_G0022304
protein coding gene Chr16:16266256-16297576 (+)
DBA/2J MGP_DBA2J_G0022436
protein coding gene Chr16:14481305-14506574 (+)
FVB/NJ MGP_FVBNJ_G0022411
protein coding gene Chr16:14526548-14553706 (+)
LP/J MGP_LPJ_G0022503
protein coding gene Chr16:15113351-15140032 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022433
protein coding gene Chr16:15938898-15965836 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023028
protein coding gene Chr16:15073310-15103376 (+)
PWK/PhJ MGP_PWKPhJ_G0021604
protein coding gene Chr16:14750923-14776700 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021432
protein coding gene Chr16:15049739-15074608 (+)
WSB/EiJ MGP_WSBEiJ_G0021908
protein coding gene Chr16:15065975-15093142 (+)



Homology
more
  • Human Ortholog
    RTN4R, reticulon 4 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTN4R, reticulon 4 receptor
  • Synonyms
    NGR, NOGOR
  • Links
    NCBI Gene ID: 65078
    neXtProt AC: NX_Q9BZR6
    UniProt: Q9BZR6

  • Chr Location
    22q11.21; chr22:20241415-20283246 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human RTN4R associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 7 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    167 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased exploration in new environment, impaired coordination, and improved recovery and rubrospinal axon regeneration following spinal cord injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65079 NCBI Gene Model | MGI Sequence Detail 24767 C57BL/6J ±  kb
    transcript NM_022982 RefSeq | MGI Sequence Detail 1938 C57BL/6  
    polypeptide Q99PI8 UniProt | EBI | MGI Sequence Detail 473 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 9
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 221
      Developmental Gene Expression 16
      Diseases 8
      Gene Ontology 14
      Phenotypes 167
    • Earliest
      J:57757 Lindsay EA, et al., Congenital heart disease in mice deficient for the DiGeorge syndrome region [see comments]. Nature. 1999 Sep 23;401(6751):379-83
    • Latest
      J:349927 Rastogi M, et al., Integrative multi-omic analysis reveals conserved cell-projection deficits in human Down syndrome brains. Neuron. 2024 May 21;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/05/2024
    MGI 6.24
    The Jackson Laboratory