Wwox MGI Mouse Gene Detail - MGI:1931237 - WW domain-containing oxidoreductase

Symbol

Wwox
Name

WW domain-containing oxidoreductase
Synonyms

5330426P09Rik, 9030416C10Rik, WOX1

Feature Type

protein coding gene
IDs

MGI:1931237
NCBI Gene: 80707
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr8:115166395-116079447 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 60.99 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

6976 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931237	protein coding gene	Chr8:115166377-116079451 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034161	protein coding gene	Chr8:117417106-118373081 (+)
A/J	MGP_AJ_G0034141	protein coding gene	Chr8:112637549-113568723 (+)
AKR/J	MGP_AKRJ_G0034068	protein coding gene	Chr8:115916949-116866906 (+)
BALB/cJ	MGP_BALBcJ_G0034135	protein coding gene	Chr8:112822510-113749638 (+)
C3H/HeJ	MGP_C3HHeJ_G0033846	protein coding gene	Chr8:116613017-117591401 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034655	protein coding gene	Chr8:121435174-122396436 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031597	protein coding gene	Chr8:105624521-106540350 (+)
CAST/EiJ	MGP_CASTEiJ_G0033173	protein coding gene	Chr8:116339846-117341255 (+)
CBA/J	MGP_CBAJ_G0033819	protein coding gene	Chr8:125721641-126758293 (+)
DBA/2J	MGP_DBA2J_G0033975	protein coding gene	Chr8:111871611-112794745 (+)
FVB/NJ	MGP_FVBNJ_G0033918	protein coding gene	Chr8:110858076-111775408 (+)
LP/J	MGP_LPJ_G0034064	protein coding gene	Chr8:117556740-118508220 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033965	protein coding gene	Chr8:128473588-129456761 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034673	protein coding gene	Chr8:115970290-116934996 (+)
PWK/PhJ	MGP_PWKPhJ_G0032875	protein coding gene	Chr8:111557482-112482630 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032715	protein coding gene	Chr8:114628651-115598734 (+)
WSB/EiJ	MGP_WSBEiJ_G0033289	protein coding gene	Chr8:116659732-117636140 (+)

Human Ortholog

WWOX, WW domain containing oxidoreductase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WWOX, WW domain containing oxidoreductase
Synonyms

D16S432E, DEE28, EIEE28, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1
Links

HGNC:12799

NCBI Gene ID: 51741

neXtProt AC: NX_Q9NZC7

UniProt: Q9NZC7
Chr Location

16q23.1-q23.2; chr16:78099413-79212667 (+) GRCh38.p7

Alliance of Genome Resources

Wwox stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WWOX
Gene Tree

Wwox

Diseases

5 with human WWOX associations

				Human Disease	Mouse Models
				autosomal recessive spinocerebellar ataxia 12 IDs autosomal recessive spinocerebellar ataxia 12 DOID:0080060 OMIM:614322
				developmental and epileptic encephalopathy 28 IDs developmental and epileptic encephalopathy 28 DOID:0080452 OMIM:616211
				esophageal cancer IDs esophageal cancer DOID:5041 DOID:10291 DOID:10292 DOID:10448 DOID:1102 DOID:1104 ICD10CM:C15.3 ICD10CM:C15.4 ICD10CM:C15.5 ICD9CM:150.2 ICD9CM:150.3 ICD9CM:150.4 ICD9CM:150.5 ICD9CM:150.8 MESH:D004938 NCI:C3028 NCI:C3533 NCI:C3534 NCI:C3535 NCI:C4764 OMIM:133239 UMLS_CUI:C0014859 UMLS_CUI:C0153413 UMLS_CUI:C0153414 UMLS_CUI:C0153415 UMLS_CUI:C0153416 UMLS_CUI:C0496775
				esophagus squamous cell carcinoma IDs esophagus squamous cell carcinoma DOID:3748 MESH:D000077277 NCI:C4024 UMLS_CUI:C0279626
				squamous cell carcinoma IDs squamous cell carcinoma DOID:1749 DOID:5512 EFO:0000707 MESH:D002294 MESH:D018307 NCI:C2929 UMLS_CUI:C0007137 UMLS_CUI:C0751688

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

79 phenotypes from 5 alleles in 6 genetic backgrounds
8 images
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Endonuclease-mediated

2
Gene trapped

22
Targeted

9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in premature death and increased incidence of tumor development. Reduced male fertility and testicular atrophy are also observed in mice with a hypomorphic allele.

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All GO Annotations

30
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

904
Tissues

150
cDNA Data

5
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wwox

ZFIN wwox

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Wwox interacts with 233 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

75
RefSeq

28
UniProt

1
CCDS

CCDS22691.1

Ensembl

ENSMUSG00000004637 (Evidence)
NCBI Gene

80707

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004637	Ensembl Gene Model \| MGI Sequence Detail	913053	C57BL/6J	± kb
transcript	ENSMUST00000004756	Ensembl \| MGI Sequence Detail	2244	Not Applicable
polypeptide	ENSMUSP00000004756	Ensembl \| MGI Sequence Detail	414	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001036 WW domain-containing oxidoreductase

(term hierarchy)
EC

1.1.1.-
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR002347 Short-chain dehydrogenase/reductase SDR

IPR001202 WW domain

IPR036020 WW domain superfamily

IPR042732 WWOX, classical (c)-like SDR domain

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 7

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MGI:1918787, MGI:1925520

Summaries

All 62

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 26
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:332267 Husanie H, et al., Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFbeta/BMP2 signaling. Cell Death Dis. 2022 Dec 27;13(12):1074

TSS for Wwox:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79540	Chr8:115166403-115166450 (+)	32 bp
Tssr79541	Chr8:115166452-115166476 (+)	69 bp
Tssr79542	Chr8:115378815-115378825 (+)	212,425 bp
Tssr79543	Chr8:115410678-115410683 (+)	244,286 bp
Tssr79544	Chr8:115473507-115473511 (+)	307,114 bp
Tssr79545	Chr8:115479480-115479481 (+)	313,086 bp
Tssr79546	Chr8:115499696-115499698 (+)	333,302 bp
Tssr79547	Chr8:115542323-115542345 (+)	375,939 bp
Tssr79548	Chr8:115596309-115596312 (+)	429,916 bp
Tssr79549	Chr8:115700115-115700130 (+)	533,728 bp
Tssr79550	Chr8:115714589-115714590 (+)	548,195 bp
Tssr79551	Chr8:115836925-115836927 (+)	670,531 bp
Tssr79552	Chr8:115837671-115837675 (+)	671,278 bp
Tssr79553	Chr8:115861162-115861166 (+)	694,769 bp
Tssr79554	Chr8:115913404-115913407 (+)	747,011 bp
Tssr79555	Chr8:115916987-115916990 (+)	750,594 bp
Tssr2694	Chr8:115921630-115921631 (+)	755,236 bp
Tssr79556	Chr8:115978213-115978216 (+)	811,820 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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