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Symbol
Name
ID

Wwox
WW domain-containing oxidoreductase
MGI:1931237

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes	Microcephaly	Progressive microcephaly	Cerebral calcification
Disease(s) Associated with WWOX	Microcephaly	Progressive microcephaly	Cerebral calcification
autosomal recessive spinocerebellar ataxia 12
developmental and epileptic encephalopathy 28

Mouse Phenotypes

abnormal osteoblast differentiation

abnormal osteoclast physiology

increased osteosarcoma incidence

increased skeletal tumor incidence

abnormal skeleton morphology

decreased bone mineral density

decreased trabecular bone volume

abnormal compact bone morphology

decreased compact bone area

decreased compact bone thickness

decreased osteoblast cell number

abnormal trabecular bone morphology

decreased bone trabecula number

decreased trabecular bone connectivity density

decreased trabecular bone thickness

abnormal skeleton development

increased bone resorption

Availability

Mouse Genotype

Wwox^tm1.1Mald/Wwox^tm1.1Mald

Wwox^tm1Ria/Wwox^tm1Ria

Wwox^tm2.1Ria/Wwox^tm2.1Ria

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23