Htra1 MGI Mouse Gene Detail - MGI:1929076

Symbol

Htra1
Name

HtrA serine peptidase 1
Synonyms

HtrA1, insulin-like growth factor binding protein 5 protease, L56, Prss11, RSPP11

Feature Type

protein coding gene
IDs

MGI:1929076
NCBI Gene: 56213
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:130537933-130587388 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 73.20 cM
Mapping Data

3 experiments

SNPs within 2kb

1453 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929076	protein coding gene	Chr7:130537841-130587390 (+)
129S1/SvImJ	ENSMUSG00200024500	protein coding gene	Chr7:117075066-117124813 (+)
A/J	ENSMUSG00195039988	protein coding gene	Chr7:121553285-121603040 (+)
AKR/J	ENSMUSG00220016220	protein coding gene	Chr7:115013919-115063661 (+)
BALB/cJ	ENSMUSG00180011470	protein coding gene	Chr7:118257794-118307558 (+)
C3H/HeJ	ENSMUSG00175017881	protein coding gene	Chr7:118984324-119034075 (+)
C57BL/6NJ	ENSMUSG00215011994	protein coding gene	Chr7:118253732-118303488 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030561	protein coding gene	Chr7:132946278-132996262 (+)
CAST/EiJ	ENSTCUG00005048290	protein coding gene	Chr7:121496464-121546541 (+)
CBA/J	ENSMUSG00210023291	protein coding gene	Chr7:118739123-118788882 (+)
DBA/2J	ENSMUSG00185022753	protein coding gene	Chr7:123055178-123104931 (+)
FVB/NJ	ENSMUSG00205034026	protein coding gene	Chr7:118689723-118739474 (+)
JF1/MsJ	ENSUMUG00000044929	protein coding gene	Chr7:128071632-128121748 (+)
LP/J	ENSMUSG00230052426	protein coding gene	Chr7:129173575-129223328 (+)
NOD/ShiLtJ	ENSMUSG00190014704	protein coding gene	Chr7:118878431-118928804 (+)
NZO/HlLtJ	ENSMUSG00225012322	protein coding gene	Chr7:127412695-127462448 (+)
PWK/PhJ	ENSLUMG00010037866	protein coding gene	Chr7:117250892-117300855 (+)
SPRET/EiJ	ENSMSPG00010010804	protein coding gene	Chr7:118524717-118574675 (+)
WSB/EiJ	ENSIUOG00005028144	protein coding gene	Chr7:119587845-119637602 (+)

Human Ortholog

HTRA1, HtrA serine peptidase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HTRA1, HtrA serine peptidase 1
Synonyms

ARMD7, CADASIL2, CARASIL, CARASIL2, HtrA, L56, ORF480, PRSS11
Links

HGNC:9476

NCBI Gene ID: 5654

UniProt: Q92743
Chr Location

10q26.13; chr10:122458551-122514907 (+) GRCh38

MGI Vertebrate Homology

Htra1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HTRA1
Gene Tree

Htra1

Diseases

11 with human HTRA1 associations

				Human Disease	Mouse Models
				age related macular degeneration IDs age related macular degeneration DOID:10871 EFO:0001365 ICD10CM:H35.30 ICD9CM:362.50 MESH:D008268 NCI:C84391 OMIM:PS603075 UMLS_CUI:C0242383
				age related macular degeneration 7 IDs age related macular degeneration 7 DOID:0110019 OMIM:610149
				autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 IDs autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 DOID:0111036 ICD10CM:F01.1 OMIM:616779
				autosomal recessive cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 IDs autosomal recessive cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 DOID:0061228 OMIM:600142
				colon cancer IDs colon cancer DOID:219 ICD10CM:C18 ICD9CM:153 ICD9CM:153.9 MESH:D003110 NCI:C9242 UMLS_CUI:C0007102
				esophagus squamous cell carcinoma IDs esophagus squamous cell carcinoma DOID:3748 MESH:D000077277 NCI:C4024 UMLS_CUI:C0279626
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				Kuhnt-Junius degeneration IDs Kuhnt-Junius degeneration DOID:10873 ICD10CM:H35.32 ICD9CM_2006:362.52 ICD9CM:362.52 UMLS_CUI:C0271084
				lung adenocarcinoma IDs lung adenocarcinoma DOID:3910 DOID:4826 EFO:0000571 MESH:D000077192 NCI:C27745 NCI:C3512 UMLS_CUI:C0152013 UMLS_CUI:C1335060
				patterned macular dystrophy IDs patterned macular dystrophy DOID:0060863 ICD10CM:H35.5 OMIM:PS169150 ORDO:99001
				vitelliform macular dystrophy IDs vitelliform macular dystrophy DOID:0050661 ICD10CM:H35.5 MESH:D057826 OMIM:153700 OMIM:153840 OMIM:608161 OMIM:616151 OMIM:616152 ORDO:1243 ORDO:99000

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
2 images
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

61
Endonuclease-mediated

13
Gene trapped

39
Targeted

8
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit normal retinal morphology. Mice homozygous for a different allele exhibit increased bone volume and increased trabecular bone thickness without body weight gain.

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All GO Annotations

32
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1016
Tissues

230
cDNA Data

101
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase htra1

ZFIN htra1a, htra1b

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All Sequences

42
RefSeq

2
UniProt

1
CCDS

CCDS21908.1

Ensembl

ENSMUSG00000006205 (Evidence)
NCBI Gene

56213

			Length	Strain/Species	Flank
genomic	56213	NCBI Gene Model \| MGI Sequence Detail	49456	C57BL/6J	± kb
transcript	NM_019564	RefSeq \| MGI Sequence Detail	2051	C57BL/6
polypeptide	Q9R118	UniProt \| EBI \| MGI Sequence Detail	480	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008838 serine protease HTRA1

(term hierarchy)
EC

3.4.21.-
InterPro Domains

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR000867 Insulin-like growth factor-binding protein, IGFBP

IPR002350 Kazal domain

IPR036058 Kazal domain superfamily

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR001940 Peptidase S1C

IPR009003 Peptidase S1, PA clan

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All nucleic 111

cDNA 102

Primer pair 6

Other 3

Antibodies 3

Microarray probesets 4

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MGI:2141952

Summaries

All 101

Developmental Gene Expression 25

Gene Ontology 12

Phenotypes 32
Earliest

J:64479 Gray CW, et al., Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. Eur J Biochem. 2000 Sep;267(18):5699-710
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Htra1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69536	Chr7:130537890-130537901 (+)	-37 bp
Tssr69537	Chr7:130537902-130537984 (+)	10 bp
Tssr69538	Chr7:130537987-130537998 (+)	60 bp
Tssr69539	Chr7:130545176-130545194 (+)	7,252 bp
Tssr69540	Chr7:130545204-130545223 (+)	7,281 bp
Tssr69541	Chr7:130550814-130550818 (+)	12,883 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24