Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables serine-type peptidase activity. Involved in proteolysis. Acts upstream of or within chorionic trophoblast cell differentiation; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and placenta development. Located in collagen-containing extracellular matrix. Is expressed in several structures, including brain; genitourinary system; heart; limb; and sensory organ. Human ortholog(s) of this gene implicated in CADASIL (multiple); gastrointestinal system cancer (multiple); hypertension; lung adenocarcinoma; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1).