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Irx6 Gene Detail
Summary
  • Symbol
    Irx6
  • Name
    Iroquois homeobox 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927642
    NCBI Gene: 64379
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:93400917-93407584 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 44.99 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927642
 protein coding gene Chr8:93400916-93407584 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033935
 protein coding gene Chr8:93980639-93987245 (+)
A/J MGP_AJ_G0033918
 protein coding gene Chr8:90277071-90283695 (+)
AKR/J MGP_AKRJ_G0033844
 protein coding gene Chr8:92821606-92828228 (+)
BALB/cJ MGP_BALBcJ_G0033910
 protein coding gene Chr8:90431917-90438458 (+)
C3H/HeJ MGP_C3HHeJ_G0033620
 protein coding gene Chr8:93522860-93529469 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034431
 protein coding gene Chr8:97447671-97454339 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031372
 protein coding gene Chr8:84195666-84202250 (+)
CAST/EiJ MGP_CASTEiJ_G0032952
 protein coding gene Chr8:93080116-93086704 (+)
CBA/J MGP_CBAJ_G0033596
 protein coding gene Chr8:100672372-100678938 (+)
DBA/2J MGP_DBA2J_G0033750
 protein coding gene Chr8:89821836-89828455 (+)
FVB/NJ MGP_FVBNJ_G0033697
 protein coding gene Chr8:88757129-88763712 (+)
LP/J MGP_LPJ_G0033842
 protein coding gene Chr8:94102637-94109243 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033739
 protein coding gene Chr8:103053724-103060340 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034449
 protein coding gene Chr8:92924080-92930741 (+)
PWK/PhJ MGP_PWKPhJ_G0032654
 protein coding gene Chr8:89169130-89175822 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032491
 protein coding gene Chr8:91787188-91793741 (+)
WSB/EiJ MGP_WSBEiJ_G0033064
 protein coding gene Chr8:93394570-93401158 (+)



Homology
more
  • Human Ortholog
    IRX6, iroquois homeobox 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRX6, iroquois homeobox 6
  • Synonyms
    IRX-3, IRX7, IRXB3
  • Links
    NCBI Gene ID: 79190
    neXtProt AC: NX_P78412
    UniProt: P78412

  • Chr Location
    16q12.2; chr16:55324203-55330756 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display abnormalities in retinal bipolar cell subtype identity and reduced electroretinography a and b wave amplitudes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    138
  • cDNA Data
    10
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64379 NCBI Gene Model | MGI Sequence Detail 6668 C57BL/6J ±  kb
    transcript NM_022428 RefSeq | MGI Sequence Detail 3369 ZRU/MplStud  
    polypeptide Q9ER75 UniProt | EBI | MGI Sequence Detail 438 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 11
      Primer pair 2
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 22
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:65170 Peters T, et al., Organization of mouse iroquois homeobox genes in two clusters suggests a conserved regulation and function in vertebrate development. Genome Res. 2000 Oct;10(10):1453-62
    • Latest
      J:333713 Narwidina A, et al., Iroquois homeobox 3 regulates odontoblast proliferation and differentiation mediated by Wnt5a expression. Biochem Biophys Res Commun. 2023 Apr 2;650:47-54
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory