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Smurf1 Gene Detail
Summary
  • Symbol
    Smurf1
  • Name
    SMAD specific E3 ubiquitin protein ligase 1
  • Synonyms
    4930431E10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923038
    NCBI Gene: 75788
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:144813305-144902657 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 84.83 cM, cytoband G2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    413 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923038
 protein coding gene Chr5:144813305-144902657 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030353
 protein coding gene Chr5:150268788-150359466 (-)
A/J MGP_AJ_G0030322
 protein coding gene Chr5:143797837-143887690 (-)
AKR/J MGP_AKRJ_G0030254
 protein coding gene Chr5:148288021-148376799 (-)
BALB/cJ MGP_BALBcJ_G0030339
 protein coding gene Chr5:145074989-145165897 (-)
C3H/HeJ MGP_C3HHeJ_G0030050
 protein coding gene Chr5:149102692-149196504 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030784
 protein coding gene Chr5:155742721-155845255 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028003
 protein coding gene Chr5:137567837-137657122 (-)
CAST/EiJ MGP_CASTEiJ_G0029455
 protein coding gene Chr5:148670205-148763554 (-)
CBA/J MGP_CBAJ_G0030020
 protein coding gene Chr5:162149104-162240007 (-)
DBA/2J MGP_DBA2J_G0030170
 protein coding gene Chr5:143538244-143628935 (-)
FVB/NJ MGP_FVBNJ_G0030125
 protein coding gene Chr5:142758328-142849171 (-)
LP/J MGP_LPJ_G0030256
 protein coding gene Chr5:150849661-150944267 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030156
 protein coding gene Chr5:164483384-164575078 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030824
 protein coding gene Chr5:148192910-148282801 (-)
PWK/PhJ MGP_PWKPhJ_G0029170
 protein coding gene Chr5:142675913-142767877 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029006
 protein coding gene Chr5:145929718-146016674 (-)
WSB/EiJ MGP_WSBEiJ_G0029528
 protein coding gene Chr5:148982829-149077892 (-)



Homology
more
  • Human Ortholog
    SMURF1, SMAD specific E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMURF1, SMAD specific E3 ubiquitin protein ligase 1
  • Links
    NCBI Gene ID: 57154
    neXtProt AC: NX_Q9HCE7
    UniProt: Q9HCE7

  • Chr Location
    7q22.1; chr7:99027440-99144108 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele display increased osteoblast function, bone density, and thickness of the cortical bone in long bones. Mice homozygous for a different knock-out allele are viable and only display gastrulation defects in combination with a Smurf2 knock-out allele.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    882
  • Tissues
    85
  • cDNA Data
    125
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75788 NCBI Gene Model | MGI Sequence Detail 89353 C57BL/6J ±  kb
    transcript NM_001038627 RefSeq | MGI Sequence Detail 5333 C57BL/6  
    polypeptide Q9CUN6 UniProt | EBI | MGI Sequence Detail 731 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 127
      cDNA 125
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 14
      Gene Ontology 8
      Phenotypes 28
    • Earliest
      J:114795 Zhu H, et al., A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. 1999 Aug 12;400(6745):687-93
    • Latest
      J:342233 Hou X, et al., Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate beta-cell proliferation and mass in mice. Cell Death Dis. 2023 Oct 31;14(10):709
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory