Smurf1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Smurf1
SMAD specific E3 ubiquitin protein ligase 1
MGI:1923038

16 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Smurf1^tm1.1Kry/Smurf1^tm1.1Kry involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J	enhanced osteoblast differentiation	J:235082
	increased bone mass	J:235082
	increased bone ossification	J:235082
	increased bone trabecula number	J:235082
	increased circulating insulin level	J:235082
	increased circulating osteocalcin level	J:235082
	increased osteoblast cell number	J:235082
	large clavicle	J:235082
	premature sagittal suture closure	J:235082
Smurf1^{tm1b(EUCOMM)Wtsi}/Smurf1⁺ C57BL/6N-Smurf1^{tm1b(EUCOMM)Wtsi}/H	trunk curl	J:211773
Smurf1^{tm1b(EUCOMM)Wtsi}/Smurf1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Smurf1^{tm1b(EUCOMM)Wtsi}/H	hyperactivity	J:211773
Smurf1^tm1Wran/Smurf1^tm1Wran involves: 129S1/Sv * 129X1/SvJ * ICR	no abnormal phenotype detected	J:148693
Smurf1^tm1Yez/Smurf1^tm1Yez either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * NIH Black Swiss)	abnormal osteoblast physiology	J:97303
	increased bone mineral density of femur	J:97303
	increased compact bone thickness	J:97303
	increased trabecular bone mass	J:97303

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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