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Grip1 Gene Detail
Summary
  • Symbol
    Grip1
  • Name
    glutamate receptor interacting protein 1
  • Synonyms
    4931400F03Rik, eb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921303
    NCBI Gene: 74053
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:119289810-119923172 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 67.33 cM, cytoband D2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20977 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921303
 protein coding gene Chr10:119289735-119923172 (+)
129S1/SvImJ ENSMUSG00200025225
 protein coding gene Chr10:116179308-116273973 (+)
129S1/SvImJ ENSMUSGG00200054599
 protein coding gene Chr10:115878621-116084397 (+)
A/J ENSMUSG00195021304
 protein coding gene Chr10:116582061-116676731 (+)
A/J ENSMUSGG00195055327
 protein coding gene Chr10:116281898-116487108 (+)
AKR/J ENSMUSGG00220054775
 protein coding gene Chr10:115917069-116119952 (+)
AKR/J ENSMUSG00220014159
 protein coding gene Chr10:116214847-116309421 (+)
BALB/cJ ENSMUSGG00180055377
 protein coding gene Chr10:116294478-116499674 (+)
BALB/cJ ENSMUSG00180015785
 protein coding gene Chr10:116594630-116689299 (+)
C3H/HeJ ENSMUSGG00175055019
 protein coding gene Chr10:116298735-116504513 (+)
C3H/HeJ ENSMUSG00175024043
 protein coding gene Chr10:116599454-116694118 (+)
C57BL/6NJ ENSMUSG00215010864
 protein coding gene Chr10:116238218-116332910 (+)
C57BL/6NJ ENSMUSGG00215055536
 protein coding gene Chr10:115937499-116143262 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015845
 protein coding gene Chr10:112084808-112716852 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054827
 protein coding gene Chr10:116135564-116341316 (+)
CBA/J ENSMUSG00210021214
 protein coding gene Chr10:116436243-116530905 (+)
DBA/2J ENSMUSGG00185057821
 protein coding gene Chr10:116245895-116451075 (+)
DBA/2J ENSMUSG00185007600
 protein coding gene Chr10:116546036-116640701 (+)
FVB/NJ ENSMUSGG00205054049
 protein coding gene Chr10:115546011-115748904 (+)
FVB/NJ ENSMUSG00205020552
 protein coding gene Chr10:115843917-115938606 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230024443
 protein coding gene Chr10:118507260-118601937 (+)
LP/J ENSMUSGG00230055291
 protein coding gene Chr10:118209402-118412274 (+)
NOD/ShiLtJ ENSMUSGG00190054542
 protein coding gene Chr10:116348898-116551766 (+)
NOD/ShiLtJ ENSMUSG00190016870
 protein coding gene Chr10:116646760-116741444 (+)
NZO/HlLtJ ENSMUSG00225036363
 protein coding gene Chr10:122757426-122851930 (+)
NZO/HlLtJ ENSMUSGG00225055362
 protein coding gene Chr10:122460212-122662609 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010015539
 protein coding gene Chr10:117613940-118241923 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GRIP1, glutamate receptor interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIP1, glutamate receptor interacting protein 1
  • Synonyms
    FRASRS3, GRIP
  • Links
    NCBI Gene ID: 23426
    UniProt: Q9Y3R0

  • Chr Location
    12q14.3; chr12:66347431-67069338 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Grip1 mouse models; 1 with human GRIP1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 4 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    6 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous ablation of gene function results in embryonic lethality and blistering skin lesions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    90
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    613
  • Tissues
    8
  • cDNA Data
    21
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74053 NCBI Gene Model | MGI Sequence Detail 633363 C57BL/6J ±  kb
    transcript NM_028736 RefSeq | MGI Sequence Detail 5219 ZRU/MplStud  
    polypeptide Q925T6 UniProt | EBI | MGI Sequence Detail 1127 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 21
      Primer pair 2
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9289, MGI:95274
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 15
      Diseases 4
      Gene Ontology 18
      Phenotypes 31
    • Earliest
      J:12164 Beasley AB, et al., Development of a mutant with abnormalities of the eye and extremities. Anat Rec. 1969;163:293 (Abstr.)
    • Latest
      J:358155 Dunham TL, et al., WWC2 modulates GABA(A)-receptor-mediated synaptic transmission, revealing class-specific mechanisms of synapse regulation by WWC family proteins. Cell Rep. 2024 Oct 22;43(10):114841
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory