About   Help   FAQ
Targeted Allele Detail
Symbol: Grip1tm1Paw
Name: glutamate receptor interacting protein 1; targeted mutation 1, Anthony Pawson
MGI ID: MGI:2449094
Synonyms: GRIP1-
Gene: Grip1  Location: Chr10:119289810-119923172 bp, + strand  Genetic Position: Chr10, 67.33 cM, cytoband D2
Alliance: Grip1tm1Paw page
Development of a severe bullous disorder in Grip1tm1Paw/Grip1tm1Paw embryos

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:79476
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3.6 kb fragment was replaced with a beta-galactosidase gene followed by a floxed neo gene. The deleted region included a 3' portion of the exon encoding the first PDZ domain. No full length protein was detected by Western blot analysis of protein extracts obtained from homozygous mutant embryos. Beta-galactosidase staining indicated that the reporter gene was expressed via the endogenous promoter. (J:79476)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grip1 Mutation:  45 strains or lines available
Original:  J:79476 Bladt F, et al., Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6816-21
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory