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Phenotypes Associated with This Genotype
involves: 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grip1tm1Paw mutation (0 available); any Grip1 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Development of a severe bullous disorder in Grip1tm1Paw/Grip1tm1Paw embryos

• Background Sensitivity: time of embryonic death is background dependent
• Background Sensitivity: no viable embryos are detected at E7.5 in a (129X1/SvJ x ICR)F1 heterozygote intercross, while expected Mendelian ratios at E12 and viable embryos are observed at E16 of a (129X1/SvJ x ICR)F3 heterozygote intercross

cardiovascular system
• hemorrhagic bulla are seen in the head

nervous system
• hemorrhagic bulla are seen in the head

• blisters form on the head, limbs, spinal cord, in the lateral ventricle of the brain, and in the meninges covering the cerebral cortex at E12 in progeny of (129X1/SvJ x ICR)F3 heterozygote intercross
• blister characterization shows cleavage of the dermo-epidermal junction below the lamina densa

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
recessive dystrophic epidermolysis bullosa DOID:0060642 OMIM:226600

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory