About   Help   FAQ
Ssu72 Gene Detail
Summary
  • Symbol
    Ssu72
  • Name
    Ssu72 RNA polymerase II CTD phosphatase homolog (yeast)
  • Synonyms
    1190002E22Rik, 1500011L16Rik, 2610101M12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916241
    NCBI Gene: 68991
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:155789272-155818336 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 87.07 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1115 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916241
 protein coding gene Chr4:155789257-155818336 (+)
129S1/SvImJ ENSMUSG00200018459
 protein coding gene Chr4:146844205-146873078 (+)
A/J ENSMUSG00195018279
 protein coding gene Chr4:148510303-148539178 (+)
AKR/J ENSMUSG00220023814
 protein coding gene Chr4:148085695-148114569 (+)
BALB/cJ ENSMUSG00180002357
 protein coding gene Chr4:146164880-146193763 (+)
C3H/HeJ ENSMUSG00175014865
 protein coding gene Chr4:149465493-149494368 (+)
C57BL/6NJ ENSMUSG00215010357
 protein coding gene Chr4:148312000-148341111 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026898
 protein coding gene Chr4:145608831-145638620 (+)
CAST/EiJ ENSTCUG00005027716
 protein coding gene Chr4:152171228-152200060 (+)
CBA/J ENSMUSG00210004348
 protein coding gene Chr4:148123850-148152725 (+)
DBA/2J ENSMUSG00185015070
 protein coding gene Chr4:151681400-151710276 (+)
FVB/NJ ENSMUSG00205020185
 protein coding gene Chr4:146578561-146607439 (+)
JF1/MsJ ENSUMUG00000000176
 protein coding gene Chr4:154713269-154742636 (+)
LP/J ENSMUSG00230021653
 protein coding gene Chr4:158406860-158435972 (+)
NOD/ShiLtJ ENSMUSG00190003611
 protein coding gene Chr4:147782366-147811240 (+)
NZO/HlLtJ ENSMUSG00225023352
 protein coding gene Chr4:162404018-162432897 (+)
PWK/PhJ ENSLUMG00010025243
 protein coding gene Chr4:146965978-146995066 (+)
SPRET/EiJ ENSMSPG00010019425
 protein coding gene Chr4:148911551-148939846 (+)
WSB/EiJ ENSIUOG00005005995
 protein coding gene Chr4:145997857-146026742 (+)



Homology
more
  • Human Ortholog
    SSU72, SSU72 homolog, RNA polymerase II CTD phosphatase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SSU72, SSU72 homolog, RNA polymerase II CTD phosphatase
  • Synonyms
    HSPC182, PNAS-120
  • Links
    NCBI Gene ID: 29101
    UniProt: Q9NP77

  • Chr Location
    1p36.33; chr1:1541673-1574884 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ssu72 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with liver-specific deletion show impaired regulation of hepatocyte chromosome polyploidization, impaired liver damage response with fibrosis, steatosis and steatohepatitis, and deregulation of hepatocyte cell cycle progression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    611
  • Tissues
    3
  • cDNA Data
    13
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68991 NCBI Gene Model | MGI Sequence Detail 29065 C57BL/6J ±  kb
    transcript NM_026899 RefSeq | MGI Sequence Detail 1478 C57BL/6  
    polypeptide Q9CY97 UniProt | EBI | MGI Sequence Detail 194 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916122, MGI:1926086
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory