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Chn1 Gene Detail
Summary
  • Symbol
    Chn1
  • Name
    chimerin 1
  • Synonyms
    0610007I19Rik, 0710001E19Rik, 1700112L09Rik, 2900046J01Rik, alpha1 chimaerin, alpha2 chimaerin, ARHGAP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915674
    NCBI Gene: 108699
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:73441004-73605690 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 43.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3393 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915674
 protein coding gene Chr2:73441004-73605723 (-)
129S1/SvImJ ENSMUSG00200035605
 protein coding gene Chr2:70509814-70559563 (-)
129S1/SvImJ ENSMUSGG00200054627
 protein coding gene Chr2:70578779-70606184 (-)
A/J ENSMUSG00195021896
 protein coding gene Chr2:70656415-70706170 (-)
A/J ENSMUSGG00195055344
 protein coding gene Chr2:70725386-70752791 (-)
AKR/J ENSMUSGG00220054822
 protein coding gene Chr2:70689994-70717395 (-)
AKR/J ENSMUSG00220038701
 protein coding gene Chr2:70621029-70670778 (-)
BALB/cJ ENSMUSGG00180055398
 protein coding gene Chr2:70679164-70706561 (-)
BALB/cJ ENSMUSG00180040221
 protein coding gene Chr2:70610195-70659946 (-)
C3H/HeJ ENSMUSG00175031793
 protein coding gene Chr2:70725092-70774839 (-)
C3H/HeJ ENSMUSGG00175055037
 protein coding gene Chr2:70794055-70821460 (-)
C57BL/6NJ ENSMUSG00215020795
 protein coding gene Chr2:70552400-70602149 (-)
C57BL/6NJ ENSMUSGG00215055439
 protein coding gene Chr2:70621365-70648780 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023662
 protein coding gene Chr2:68427126-68584825 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210002301
 protein coding gene Chr2:70767813-70817558 (-)
CBA/J ENSMUSGG00210054727
 protein coding gene Chr2:70836774-70864174 (-)
DBA/2J ENSMUSG00185039315
 protein coding gene Chr2:70603622-70653371 (-)
DBA/2J ENSMUSGG00185057586
 protein coding gene Chr2:70672587-70699996 (-)
FVB/NJ ENSMUSG00205027057
 protein coding gene Chr2:70066439-70116188 (-)
FVB/NJ ENSMUSGG00205054313
 protein coding gene Chr2:70135405-70162809 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230025081
 protein coding gene Chr2:72409489-72459236 (-)
LP/J ENSMUSGG00230055804
 protein coding gene Chr2:72478452-72505856 (-)
NOD/ShiLtJ ENSMUSG00190036847
 protein coding gene Chr2:70689143-70738890 (-)
NOD/ShiLtJ ENSMUSGG00190054987
 protein coding gene Chr2:70758102-70785506 (-)
NZO/HlLtJ ENSMUSG00225014128
 protein coding gene Chr2:80152990-80202736 (-)
NZO/HlLtJ ENSMUSGG00225055412
 protein coding gene Chr2:80221952-80249357 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CHN1, chimerin 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHN1, chimerin 1
  • Synonyms
    ARHGAP2, CHN, DURS2, NC, RHOGAP2
  • Links
    NCBI Gene ID: 1123
    UniProt: P15882

  • Chr Location
    2q31.1; chr2:174798809-175005381 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Chn1 mouse models; 1 with human CHN1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 11 alleles in 10 genetic backgrounds
    8 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homologous for a null allele exhibit transient postnatal size reduction, abnormal gait and abnormal innervation of the spinal cord.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    686
  • Tissues
    57
  • cDNA Data
    96
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056486 Ensembl Gene Model | MGI Sequence Detail 164687 C57BL/6J ±  kb
    transcript ENSMUST00000112024 Ensembl | MGI Sequence Detail 4050 Not Applicable  
    polypeptide ENSMUSP00000107655 Ensembl | MGI Sequence Detail 459 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 97

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1915574, MGI:1923974, MGI:1925592, MGI:2138925
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 4
      Phenotypes 40
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:373797 Hintermann A, et al., Co-option of an ancestral cloacal regulatory landscape during digit evolution. Nature. 2025 Sep 17;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory