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Phenotypes Associated with This Genotype
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chn1tm1.1Ece mutation (0 available); any Chn1 mutation (38 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• 71.8% penetrance of unilateral or bilateral globe retraction

nervous system
• the abducens nerve has fewer hindbrain exiting bundles that are over-fasciculated in the hindbrain
• the abducens nerve has fewer hindbrain exiting bundles (30% reduction) that are over-fasciculated in the hindbrain and stalled with variable penetrance midway between the hindbrain and orbit at E11.5
• stalled abducens nerve bundles do not reach the orbit, resulting in secondary aberrant misinnervation of the lateral rectus muscle by the oculomotor nerve
• E11.5 embryos show errors in trochlear nerve projections; trochlear axons cross the midline and exit dorsally as in wild-type embryos, but the axons form multiple fascicles instead of one nerve bundle, most of which extend appropriately toward the contralateral orbit, but some turn back and misproject toward the ipsilateral orbit
• in E11.5 embryos, the first cervical spine nerve exits the brainstem appropriately, but turns dorsally toward the dermomyotome with variable bilateral penetrance
• embryos show an absence or thinning of the abducens nerve at the primitive extraocular muscles anlage at the orbit, as seen by a reduction in abducens nerve diameter near the orbit

• the abducens nerve has fewer hindbrain exiting bundles that are over-fasciculated in the hindbrain

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Duane retraction syndrome DOID:12557 OMIM:126800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory