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Rab39b Gene Detail
Summary
  • Symbol
    Rab39b
  • Name
    RAB39B, member RAS oncogene family
  • Synonyms
    6330580M05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915040
    NCBI Gene: 67790
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:74615652-74621837 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 38.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915040
 protein coding gene ChrX:74615651-74621837 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035862
 protein coding gene ChrX:71423447-71429637 (-)
A/J MGP_AJ_G0035849
 protein coding gene ChrX:71648485-71654670 (-)
AKR/J MGP_AKRJ_G0035770
 protein coding gene ChrX:73483805-73489990 (-)
BALB/cJ MGP_BALBcJ_G0035831
 protein coding gene ChrX:70645036-70651221 (-)
C3H/HeJ MGP_C3HHeJ_G0035541
 protein coding gene ChrX:71913883-71920068 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036361
 protein coding gene ChrX:73711657-73717842 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0034827
 protein coding gene ChrX:57240633-57246820 (-)
CBA/J MGP_CBAJ_G0035514
 protein coding gene ChrX:75681709-75687894 (-)
DBA/2J MGP_DBA2J_G0035672
 protein coding gene ChrX:71089378-71095563 (-)
FVB/NJ MGP_FVBNJ_G0035613
 protein coding gene ChrX:70417457-70423647 (-)
LP/J MGP_LPJ_G0035754
 protein coding gene ChrX:72233783-72239973 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035647
 protein coding gene ChrX:78301677-78307867 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036387
 protein coding gene ChrX:71287036-71293221 (-)
PWK/PhJ MGP_PWKPhJ_G0034524
 protein coding gene ChrX:55254681-55260870 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034360
 protein coding gene ChrX:58060065-58066247 (-)
WSB/EiJ MGP_WSBEiJ_G0034966
 protein coding gene ChrX:70497264-70503450 (-)



Homology
more
  • Human Ortholog
    RAB39B, RAB39B, member RAS oncogene family
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB39B, RAB39B, member RAS oncogene family
  • Synonyms
    BGMR, MRX72, WSMN, WSN, XLID72
  • Links
    NCBI Gene ID: 116442
    neXtProt AC: NX_Q96DA2
    UniProt: Q96DA2

  • Chr Location
    Xq28; chrX:155258235-155264491 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Rab39b mouse models; 2 with human RAB39B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout in females results in increased brain size and decreased body weight and, in hemizygous KO in males, social memory and motor learning deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    12
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031202 Ensembl Gene Model | MGI Sequence Detail 6186 C57BL/6J ±  kb
    transcript ENSMUST00000033545 Ensembl | MGI Sequence Detail 3401 Not Applicable  
    polypeptide ENSMUSP00000033545 Ensembl | MGI Sequence Detail 213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 20
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 11
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:341888 Mignogna ML, et al., Clinical characterization of a novel RAB39B nonstop mutation in a family with ASD and severe ID causing RAB39B downregulation and study of a Rab39b knock down mouse model. Hum Mol Genet. 2022 May 4;31(9):1389-1406
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory