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Qprt Gene Detail
Summary
  • Symbol
    Qprt
  • Name
    quinolinate phosphoribosyltransferase
  • Synonyms
    2410027J01Rik, nicotinate-nucleotide pyrophosphorylase, QPRTase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914625
    NCBI Gene: 67375
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126706942-126721201 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    509 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914625
 protein coding gene Chr7:126706286-126721398 (-)
129S1/SvImJ ENSMUSG00200021429
 protein coding gene Chr7:113217959-113233074 (-)
A/J ENSMUSG00195036837
 protein coding gene Chr7:117734092-117749217 (-)
AKR/J ENSMUSG00220021808
 protein coding gene Chr7:111166805-111181925 (-)
BALB/cJ ENSMUSG00180013078
 protein coding gene Chr7:114407637-114422756 (-)
C3H/HeJ ENSMUSG00175016430
 protein coding gene Chr7:115134664-115149779 (-)
C57BL/6NJ ENSMUSG00215027213
 protein coding gene Chr7:114414637-114429754 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030487
 protein coding gene Chr7:129145284-129161348 (-)
CAST/EiJ ENSTCUG00005045611
 protein coding gene Chr7:117632785-117647802 (-)
CBA/J ENSMUSG00210022853
 protein coding gene Chr7:114895729-114910842 (-)
DBA/2J ENSMUSG00185037837
 protein coding gene Chr7:119208575-119223692 (-)
FVB/NJ ENSMUSG00205018970
 protein coding gene Chr7:114851489-114866607 (-)
JF1/MsJ ENSUMUG00000032348
 protein coding gene Chr7:124263211-124283328 (-)
LP/J ENSMUSG00230052935
 protein coding gene Chr7:125317934-125333047 (-)
NOD/ShiLtJ ENSMUSG00190015702
 protein coding gene Chr7:115055208-115070324 (-)
NZO/HlLtJ ENSMUSG00225012159
 protein coding gene Chr7:123547889-123563007 (-)
PWK/PhJ ENSLUMG00010033215
 protein coding gene Chr7:113402184-113417321 (-)
SPRET/EiJ ENSMSPG00010011608
 protein coding gene Chr7:114667288-114682538 (-)
WSB/EiJ ENSIUOG00005025080
 protein coding gene Chr7:115757038-115772162 (-)



Homology
more
  • Human Ortholog
    QPRT, quinolinate phosphoribosyltransferase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    QPRT, quinolinate phosphoribosyltransferase
  • Synonyms
    HEL-S-90n, QPRTase
  • Links
    NCBI Gene ID: 23475
    UniProt: Q15274

  • Chr Location
    16p11.2; chr16:29663279-29698704 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Qprt mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal mitochondrial morphology and physiology in peritoneal macrophages and increased proinflammatory cytokines under basal and LPS-stimulated conditions. Mice homozygous for a different null allele show decreased food intake and body weight, lower active forms of niacin concentration in blood and tissues, loss of the inner circular layer of smooth muscle cells in the small intestine, and do not excrete nicotinamide and its catabolites when fed a nicotinic acid-free diet. Brain samples from adult heterozygous males show decreased corpus callosum and brain internal capsule size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    97
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67375 NCBI Gene Model | MGI Sequence Detail 14260 C57BL/6J ±  kb
    transcript NM_133686 RefSeq | MGI Sequence Detail 1211 FVB/N  
    polypeptide Q91X91 UniProt | EBI | MGI Sequence Detail 299 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000013567 nicotinate-nucleotide pyrophosphorylase [carboxylating]
      (term hierarchy)
    • EC
      2.4.2.19
    • InterPro Domains
      IPR013785 Aldolase-type TIM barrel
      IPR004393 Nicotinate-nucleotide pyrophosphorylase
      IPR027277 Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD
      IPR036068 Nicotinate phosphoribosyltransferase-like, C-terminal
      IPR002638 Quinolinate phosphoribosyl transferase, C-terminal
      IPR022412 Quinolinate phosphoribosyl transferase, N-terminal
      IPR037128 Quinolinate phosphoribosyl transferase, N-terminal domain superfamily
    • GlyGen
      Q91X91 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142018
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 2
      Diseases 4
      Gene Ontology 16
      Phenotypes 63
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:389705 Hao L, et al., Heart rate and sleep history encode ultradian REM sleep timing. Curr Biol. 2026 Mar 23;36(6):1422-1434.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory