Analysis Tools
growth/size/body
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• in mice fed a nicotinic acid (NiA)-free diet, body weight is reduced to 70% of the body weight on a complete diet that contains preformed niacin
• however, mice fed a complete diet show normal body weight and tissue weights
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behavior/neurological
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• in mice fed a nicotinic acid (NiA)-free diet, food intake is reduced to 60% of the food intake on a complete diet
• however, mice fed a complete diet show normal food intake
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digestive/alimentary system
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• the inner circular layer of smooth muscle cells in the small intestine disappears in mice fed a NiA-free diet
• however, mice fed a complete diet show normal small intestine
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homeostasis/metabolism
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• mice fed a NiA-free diet exhibit lower nicotinamide adenine dinucleotide (NAD; NAD+ and NADH) concentrations in blood, suggesting that mice are niacin deficient
• however, mice fed a complete diet show normal levels of NAD
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• mice show extremely high urinary excretion of quinolinic acid regardless of diet type
• mice fed a NiA-free diet do not excrete nicotinamide (Nam) and its catabolites
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• mice fed a NiA-free diet exhibit lower active forms of niacin (nicotinamide adenine dinucleotide or NAD; NAD+ and NADH) concentration in blood and in tissues, especially in the small intestine, suggesting that mice are niacin deficient and indicating that mice cannot synthesize niacin from L-tryptophan
• however, mice fed a complete diet show normal levels of NAD in blood and tissues
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• quinolinic acid phosphoribosyltransferase (QPRT) activity is not detected
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muscle
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• the inner circular layer of smooth muscle cells in the small intestine disappears in mice fed a NiA-free diet
• however, mice fed a complete diet show normal small intestine
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renal/urinary system
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• mice show extremely high urinary excretion of quinolinic acid regardless of diet type
• mice fed a NiA-free diet do not excrete nicotinamide (Nam) and its catabolites
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