Qprt^tm1Kshib
Targeted Allele Detail

Summary

• Symbol: Qprt^tm1Kshib
• Name: quinolinate phosphoribosyltransferase; targeted mutation 1, Katsumi Shibata
• MGI ID: MGI:8209546
• Gene: Qprt Location: Chr7:126706942-126721201 bp, - strand Genetic Position: Chr7, 69.33 cM
• Alliance: Qprt^tm1Kshib page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:361891
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-3 were replaced with a PGK-neomycin cassette via homologous recombination. Southern blot analysis confirmed the absence of DNA expression. (J:361891)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Qprt Mutation: 18 strains or lines available

Notes

The authors report the Genome Systems 129SvJ embryonic stem cell line was used for gene targeting.

References

• Original: J:361891 Terakata M, et al., Establishment of true niacin deficiency in quinolinic acid phosphoribosyltransferase knockout mice. J Nutr. 2012 Dec;142(12):2148-53
• All: 2 reference(s)