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Grina Gene Detail
Summary
  • Symbol
    Grina
  • Name
    glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
  • Synonyms
    1110025J15Rik, Tmbim3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913418
    NCBI Gene: 66168
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76130964-76134104 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.59 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913418
 protein coding gene Chr15:76130917-76134109 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021979
 protein coding gene Chr15:76310392-76313489 (+)
A/J MGP_AJ_G0021937
 protein coding gene Chr15:73533372-73536469 (+)
AKR/J MGP_AKRJ_G0021920
 protein coding gene Chr15:75526593-75529690 (+)
BALB/cJ MGP_BALBcJ_G0021946
 protein coding gene Chr15:73560749-73563846 (+)
C3H/HeJ MGP_C3HHeJ_G0021718
 protein coding gene Chr15:75574150-75577247 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022386
 protein coding gene Chr15:79163270-79166367 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019915
 protein coding gene Chr15:70195716-70198810 (+)
CAST/EiJ MGP_CASTEiJ_G0021237
 protein coding gene Chr15:76375011-76378116 (+)
CBA/J MGP_CBAJ_G0021685
 protein coding gene Chr15:81662700-81665797 (+)
DBA/2J MGP_DBA2J_G0021810
 protein coding gene Chr15:73071070-73074167 (+)
FVB/NJ MGP_FVBNJ_G0021791
 protein coding gene Chr15:72117756-72120853 (+)
LP/J MGP_LPJ_G0021881
 protein coding gene Chr15:76403539-76406636 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021815
 protein coding gene Chr15:86986266-86989363 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022406
 protein coding gene Chr15:75769943-75773040 (+)
PWK/PhJ MGP_PWKPhJ_G0020978
 protein coding gene Chr15:73216661-73219759 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020818
 protein coding gene Chr15:75491862-75494964 (+)
WSB/EiJ MGP_WSBEiJ_G0021289
 protein coding gene Chr15:75862387-75865491 (+)



Homology
more
  • Human Ortholog
    GRINA, glutamate ionotropic receptor NMDA type subunit associated protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRINA, glutamate ionotropic receptor NMDA type subunit associated protein 1
  • Synonyms
    HNRGW, LFG1, NMDARA1, TMBIM3
  • Links
    NCBI Gene ID: 2907
    UniProt: Q7Z429

  • Chr Location
    8q24.3; chr8:143990056-143993415 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    31 phenotype references
Mice homozygous for a null allele exhibit no significant alterations in behavior, histopathology or clinical chemistry.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    20
  • cDNA Data
    180
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022564 Ensembl Gene Model | MGI Sequence Detail 3141 C57BL/6J ±  kb
transcript ENSMUST00000023225 Ensembl | MGI Sequence Detail 1725 Not Applicable  
polypeptide ENSMUSP00000023225 Ensembl | MGI Sequence Detail 345 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 180
    cDNA 180

    Microarray probesets 5
References
more
  • Summaries
    All 61
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 7
    Phenotypes 31
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:374210 Lai C, et al., Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics. Cell Discov. 2025 Feb 25;11(1):16
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory