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Adam33 Gene Detail
Summary
  • Symbol
    Adam33
  • Name
    a disintegrin and metallopeptidase domain 33
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341813
    NCBI Gene: 110751
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:130892739-130905734 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.26 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341813
 protein coding gene Chr2:130892511-130905734 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026519
 protein coding gene Chr2:134553505-134568550 (-)
A/J MGP_AJ_G0026483
 protein coding gene Chr2:129097974-129111213 (-)
AKR/J MGP_AKRJ_G0026458
 protein coding gene Chr2:132833821-132847048 (-)
BALB/cJ MGP_BALBcJ_G0026495
 protein coding gene Chr2:129485729-129498970 (-)
C3H/HeJ MGP_C3HHeJ_G0026238
 protein coding gene Chr2:133259573-133272791 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026940
 protein coding gene Chr2:138695880-138715506 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024317
 protein coding gene Chr2:123836902-123849950 (-)
CAST/EiJ MGP_CASTEiJ_G0025699
 protein coding gene Chr2:133534166-133549390 (-)
CBA/J MGP_CBAJ_G0026218
 protein coding gene Chr2:143849285-143862507 (-)
DBA/2J MGP_DBA2J_G0026352
 protein coding gene Chr2:128491412-128505142 (-)
FVB/NJ MGP_FVBNJ_G0026316
 protein coding gene Chr2:127118400-127132693 (-)
LP/J MGP_LPJ_G0026457
 protein coding gene Chr2:134793568-134808009 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026336
 protein coding gene Chr2:147670043-147683303 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026995
 protein coding gene Chr2:132783377-132797368 (-)
PWK/PhJ MGP_PWKPhJ_G0025435
 protein coding gene Chr2:128053058-128067180 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025237
 protein coding gene Chr2:131934971-131950680 (-)
WSB/EiJ MGP_WSBEiJ_G0025773
 protein coding gene Chr2:133707997-133721360 (-)



Homology
more
  • Human Ortholog
    ADAM33, ADAM metallopeptidase domain 33
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM33, ADAM metallopeptidase domain 33
  • Synonyms
    C20orf153, DJ964F7.1
  • Links
    NCBI Gene ID: 80332
    neXtProt AC: NX_Q9BZ11
    UniProt: Q9BZ11

  • Chr Location
    20p13; chr20:3667973-3682131 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    3 with human ADAM33 associations

Human Disease Mouse Models
      
IDs
 View 1 "NOT" model
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted gene deletion are viable, fertile, developmentally normal and display normal allergen-induced airway hyperreactivity, IgE production, mucus metaplasia, and airway inflammation in an OVA-induced model of allergic asthma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    24
  • cDNA Data
    20
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110751 NCBI Gene Model | MGI Sequence Detail 12996 C57BL/6J ±  kb
    transcript NM_033615 RefSeq | MGI Sequence Detail 3176 C57BL/6  
    polypeptide Q923W9 UniProt | EBI | MGI Sequence Detail 797 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 2
      cDNA 21
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    01/24/2023
    MGI 6.22     		The Jackson Laboratory