About   Help   FAQ
Targeted Allele Detail
Symbol: Adam33tm1.1Chch
Name: a disintegrin and metallopeptidase domain 33; targeted mutation 1.1, Chun Chen
MGI ID: MGI:3664558
Synonyms: ADAM33-
Gene: Adam33  Location: Chr2:130892739-130905734 bp, - strand  Genetic Position: Chr2, 63.26 cM
Alliance: Adam33tm1.1Chch page
Germline Transmission:  Earliest citation of germline transmission: J:112306
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe floxed exon 1 and neomycin resistance gene in Adam 33tm1Chch were removed via cre mediated recombination by mating with Tg(Tek-cre)1Rwng mice. Successful gene disruption was demonstrated by QRT-PCR, however LacZ expression was not detected. (J:112306)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam33 Mutation:  43 strains or lines available
Original:  J:112306 Chen C, et al., ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. Mol Cell Biol. 2006 Sep;26(18):6950-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.13
The Jackson Laboratory