Vamp1 MGI Mouse Gene Detail - MGI:1313276 - vesicle-associated membrane protein 1

Symbol

Vamp1
Name

vesicle-associated membrane protein 1
Synonyms

lew, Syb1, Syb-1, VAMP-1

Feature Type

protein coding gene
IDs

MGI:1313276
NCBI Gene: 22317
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:125192544-125199269 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.32 cM
Mapping Data

5 experiments

SNPs within 2kb

37 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1313276	protein coding gene	Chr6:125192514-125222927 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031291	protein coding gene	Chr6:128556550-128586995 (+)
A/J	MGP_AJ_G0031261	protein coding gene	Chr6:123701448-123732029 (+)
AKR/J	MGP_AKRJ_G0031189	protein coding gene	Chr6:127081525-127111878 (+)
BALB/cJ	MGP_BALBcJ_G0031269	protein coding gene	Chr6:123298867-123329236 (+)
C3H/HeJ	MGP_C3HHeJ_G0030992	protein coding gene	Chr6:127150095-127180784 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031725	protein coding gene	Chr6:131945647-131976025 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028874	protein coding gene	Chr6:120911235-120918201 (+)
CAST/EiJ	MGP_CASTEiJ_G0030373	protein coding gene	Chr6:127357631-127389995 (+)
CBA/J	MGP_CBAJ_G0030953	protein coding gene	Chr6:136992179-137022954 (+)
DBA/2J	MGP_DBA2J_G0031109	protein coding gene	Chr6:122633255-122663821 (+)
FVB/NJ	MGP_FVBNJ_G0031059	protein coding gene	Chr6:121546270-121577075 (+)
LP/J	MGP_LPJ_G0031189	protein coding gene	Chr6:128714593-128747244 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031097	protein coding gene	Chr6:141023530-141053998 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031760	protein coding gene	Chr6:126983292-127013738 (+)
PWK/PhJ	MGP_PWKPhJ_G0030088	protein coding gene	Chr6:120877137-120907897 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029917	protein coding gene	Chr6:125057892-125090153 (+)
WSB/EiJ	MGP_WSBEiJ_G0030458	protein coding gene	Chr6:127351340-127381757 (+)

Human Ortholog

VAMP1, vesicle associated membrane protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VAMP1, vesicle associated membrane protein 1
Synonyms

CMS25, SAX1, SPAX1, SYB1, VAMP-1
Links

HGNC:12642

NCBI Gene ID: 6843

neXtProt AC: NX_P23763

UniProt: P23763
Chr Location

12p13.31; chr12:6462237-6470677 (-) GRCh38

MGI Vertebrate Homology

Vamp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: VAMP1
Protein SuperFamily

Synaptobrevin_euk
Gene Tree

Vamp1

Diseases

2 with human VAMP1 associations

				Human Disease	Mouse Models
				congenital myasthenic syndrome IDs congenital myasthenic syndrome DOID:3635 MESH:D020294 NCI:C84647 OMIM:PS601462 ORDO:590 UMLS_CUI:C0751882
				spastic ataxia 1 IDs spastic ataxia 1 DOID:0050772 OMIM:108600

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Gene trapped

13
Spontaneous

1
Targeted

2
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a spontaneous mutation show a 30% reduction in body size, do not attempt to right themselves, become visibly immobile and lay on their side by postnatal day 10, and display a general lack of purposeful movement and wasting leading to death prior to weaning.

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All GO Annotations

22
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

8
cDNA Data

37
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vamp1

ZFIN vamp1a, vamp1b

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All Sequences

54
RefSeq

4
UniProt

5
CCDS

CCDS20546.1, CCDS39637.1

Ensembl

ENSMUSG00000030337 (Evidence)
NCBI Gene

22317

			Length	Strain/Species	Flank
genomic	22317	NCBI Gene Model \| MGI Sequence Detail	6726	C57BL/6J	± kb
transcript	NM_001080557	RefSeq \| MGI Sequence Detail	3170	ZRU/MplStud
polypeptide	Q62442	UniProt \| EBI \| MGI Sequence Detail	118	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017248 vesicle-associated membrane protein 1

(term hierarchy)
InterPro Domains

IPR036280 Multiheme cytochrome superfamily

IPR001388 Synaptobrevin-like

IPR016444 Synaptobrevin/Vesicle-associated membrane protein

IPR042855 v-SNARE, coiled-coil homology domain

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All nucleic 39

cDNA 38

Primer pair 1

Microarray probesets 7

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MGD-MRK-14675, MGD-MRK-14677, MGI:2449156, MGI:98458

Summaries

All 52

Developmental Gene Expression 6

Gene Ontology 9

Phenotypes 9
Earliest

J:10766 Archer BT 3rd, et al., Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. J Biol Chem. 1990 Oct 5;265(28):17267-73
Latest

J:299884 Hoogstraaten RI, et al., Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons. Sci Rep. 2020 Jul 2;10(1):10913

TSS for Vamp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58930	Chr6:125192339-125192353 (+)	-198 bp
Tssr58931	Chr6:125192535-125192554 (+)	1 bp
Tssr58932	Chr6:125195944-125195957 (+)	3,407 bp
Tssr58933	Chr6:125198687-125198698 (+)	6,149 bp
Tssr58934	Chr6:125198788-125198804 (+)	6,252 bp
Tssr58935	Chr6:125198852-125198866 (+)	6,315 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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