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Cited2 Gene Detail
Summary
  • Symbol
    Cited2
  • Name
    Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
  • Synonyms
    Mrg1, Msg2, p35srj
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306784
    NCBI Gene: 17684
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:17598966-17601422 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 7.18 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306784
 protein coding gene Chr10:17598452-17601422 (+)
129S1/SvImJ ENSMUSG00200009057
 protein coding gene Chr10:14585414-14587870 (+)
A/J ENSMUSG00195006583
 protein coding gene Chr10:14596553-14599009 (+)
AKR/J ENSMUSG00220010064
 protein coding gene Chr10:14507612-14510068 (+)
BALB/cJ ENSMUSG00180014989
 protein coding gene Chr10:14720871-14723327 (+)
C3H/HeJ ENSMUSG00175019459
 protein coding gene Chr10:14740786-14743242 (+)
C57BL/6NJ ENSMUSG00215003588
 protein coding gene Chr10:14549750-14552206 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015134
 protein coding gene Chr10:13700916-13703366 (+)
CAST/EiJ ENSTCUG00005029819
 protein coding gene Chr10:14513581-14516037 (+)
CBA/J ENSMUSG00210015154
 protein coding gene Chr10:14678426-14680882 (+)
DBA/2J ENSMUSG00185006907
 protein coding gene Chr10:14662919-14665375 (+)
FVB/NJ ENSMUSG00205016942
 protein coding gene Chr10:14567580-14570037 (+)
JF1/MsJ ENSUMUG00000008638
 protein coding gene Chr10:14732412-14734868 (+)
LP/J ENSMUSG00230017181
 protein coding gene Chr10:16319462-16321918 (+)
NOD/ShiLtJ ENSMUSG00190010163
 protein coding gene Chr10:14649401-14651857 (+)
NZO/HlLtJ ENSMUSG00225029981
 protein coding gene Chr10:20808712-20811168 (+)
PWK/PhJ ENSLUMG00010015187
 protein coding gene Chr10:14456747-14459207 (+)
SPRET/EiJ ENSMSPG00010010636
 protein coding gene Chr10:15052296-15054754 (+)
WSB/EiJ ENSIUOG00005021252
 protein coding gene Chr10:14265650-14268106 (+)



Homology
more
  • Human Ortholog
    CITED2, Cbp/p300 interacting transactivator with ED-rich tail 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CITED2, Cbp/p300 interacting transactivator with ED-rich tail 2
  • Synonyms
    ASD8, MRG-1, MRG1, P35SRJ, VSD2
  • Links
    NCBI Gene ID: 10370
    UniProt: Q99967

  • Chr Location
    6q24.1; chr6:139371807-139375909 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cited2 mouse models; 2 with human CITED2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    90 phenotypes from 12 alleles in 15 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this locus cause cardiac malformations, lethality between E13.5-18.5, neural tube defects, exencephaly, hydrops fetalis, small size, abnormal embryo turning, situs inversus, small spleen, dorsal root and cranial ganglia abnormalities, impaired kidney development and iris coloboma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    157
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1001
  • Tissues
    316
  • cDNA Data
    127
  • Literature Summary
    52
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039910 Ensembl Gene Model | MGI Sequence Detail 2457 C57BL/6J ±  kb
    transcript ENSMUST00000038107 Ensembl | MGI Sequence Detail 1979 Not Applicable  
    polypeptide ENSMUSP00000038405 Ensembl | MGI Sequence Detail 269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      cDNA 128
      Primer pair 5
      Other 7
      Antibodies 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143671
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 52
      Diseases 1
      Gene Ontology 29
      Phenotypes 53
    • Earliest
      J:48778 Shioda T, et al., MSG1 and its related protein MRG1 share a transcription activating domain. Gene. 1997 Dec 19;204(1-2):235-41
    • Latest
      J:382699 Mendes-Silva L, et al., Acute Depletion of Cited2 in Embryonic Stem Cells Disrupts Gene Networks Controlling Self-Renewal, Homeostasis, and Early Cell Fate Commitment. Cells. 2026 Mar 3;15(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory