Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including SMAD binding activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including adrenal cortex formation; heart morphogenesis; and left/right pattern formation. Acts upstream of or within several processes, including circulatory system development; embryo development; and hemopoiesis. Located in nucleus. Part of chromatin. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and sensory organ. Used to study tetralogy of Fallot. Human ortholog(s) of this gene implicated in atrial heart septal defect 8 and ventricular septal defect. Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2).