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Sucla2 Gene Detail
Summary
  • Symbol
    Sucla2
  • Name
    succinate-Coenzyme A ligase, ADP-forming, beta subunit
  • Synonyms
    4930547K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306775
    NCBI Gene: 20916
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:73790226-73833584 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 39.06 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    457 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306775
 protein coding gene Chr14:73762759-73833584 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021561
 protein coding gene Chr14:68319825-68364273 (+)
A/J MGP_AJ_G0021519
 protein coding gene Chr14:66812194-66855570 (+)
AKR/J MGP_AKRJ_G0021496
 protein coding gene Chr14:68744317-68822701 (+)
BALB/cJ MGP_BALBcJ_G0021526
 protein coding gene Chr14:66580427-66627861 (+)
C3H/HeJ MGP_C3HHeJ_G0021303
 protein coding gene Chr14:68502826-68547703 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021966
 protein coding gene Chr14:71314426-71362022 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019504
 protein coding gene Chr14:64538403-64579061 (+)
CAST/EiJ MGP_CASTEiJ_G0020820
 protein coding gene Chr14:65144431-65237426 (+)
CBA/J MGP_CBAJ_G0021271
 protein coding gene Chr14:73558228-73604338 (+)
DBA/2J MGP_DBA2J_G0021394
 protein coding gene Chr14:66193431-66239562 (+)
FVB/NJ MGP_FVBNJ_G0021372
 protein coding gene Chr14:65573662-65618153 (+)
LP/J MGP_LPJ_G0021464
 protein coding gene Chr14:69482159-69523731 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021399
 protein coding gene Chr14:72388694-72432608 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021989
 protein coding gene Chr14:68059786-68106892 (+)
PWK/PhJ MGP_PWKPhJ_G0020563
 protein coding gene Chr14:62979623-63054321 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020399
 protein coding gene Chr14:64017154-64061226 (+)
WSB/EiJ MGP_WSBEiJ_G0020873
 protein coding gene Chr14:68419390-68465497 (+)



Homology
more
  • Human Ortholog
    SUCLA2, succinate-CoA ligase ADP-forming subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUCLA2, succinate-CoA ligase ADP-forming subunit beta
  • Synonyms
    A-BETA, A-SCS, LINC00444, MTDPS5, SCS-betaA
  • Links
    NCBI Gene ID: 8803
    neXtProt AC: NX_Q9P2R7
    UniProt: Q9P2R7

  • Chr Location
    13q14.2; chr13:47745736-48037968 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sucla2 mouse models; 1 with human SUCLA2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit perinatal lethality with reduced size, placenta mineralization, decreased mitochondrial DNA and respiration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    867
  • Tissues
    105
  • cDNA Data
    19
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20916 NCBI Gene Model | MGI Sequence Detail 43359 C57BL/6J ±  kb
    transcript NM_011506 RefSeq | MGI Sequence Detail 2110 C57BL/6  
    polypeptide Q9Z2I9 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015811 succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
      (term hierarchy)
    • EC
      6.2.1.-, 6.2.1.5
    • InterPro Domains
      IPR005811 ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain
      IPR011761 ATP-grasp fold
      IPR013815 ATP-grasp fold, subdomain 1
      IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
      IPR034723 Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
      IPR005809 Succinate--CoA ligase-like, beta subunit
      IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
      IPR016102 Succinyl-CoA synthetase-like
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1922515
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 11
      Phenotypes 11
    • Earliest
      J:50333 Johnson JD, et al., Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. J Biol Chem. 1998 Oct 16;273(42):27580-6
    • Latest
      J:342100 Lancaster MS, et al., Loss of succinyl-CoA synthetase in mouse forebrain results in hypersuccinylation with perturbed neuronal transcription and metabolism. Cell Rep. 2023 Oct 10;42(10):113241
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory