Mpzl2 MGI Mouse Gene Detail - MGI:1289160 - myelin protein zero-like 2

Symbol

Mpzl2
Name

myelin protein zero-like 2
Synonyms

Eva, Eva1

Feature Type

protein coding gene
IDs

MGI:1289160
NCBI Gene: 14012
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:44951595-44965341 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM
Mapping Data

3 experiments

SNPs within 2kb

405 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1289160	protein coding gene	Chr9:44951097-44965341 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034727	protein coding gene	Chr9:43582124-43594251 (+)
A/J	MGP_AJ_G0034708	protein coding gene	Chr9:42366453-42378979 (+)
AKR/J	MGP_AKRJ_G0034635	protein coding gene	Chr9:43240538-43254087 (+)
BALB/cJ	MGP_BALBcJ_G0034699	protein coding gene	Chr9:42099058-42110855 (+)
C3H/HeJ	MGP_C3HHeJ_G0034410	protein coding gene	Chr9:43692940-43705320 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035220	protein coding gene	Chr9:44860954-44874229 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032135	protein coding gene	Chr9:41918563-41929996 (+)
CAST/EiJ	MGP_CASTEiJ_G0033732	protein coding gene	Chr9:43558007-43570804 (+)
CBA/J	MGP_CBAJ_G0034382	protein coding gene	Chr9:46505573-46522323 (+)
DBA/2J	MGP_DBA2J_G0034541	protein coding gene	Chr9:42256469-42268003 (+)
FVB/NJ	MGP_FVBNJ_G0034482	protein coding gene	Chr9:41512239-41525087 (+)
LP/J	MGP_LPJ_G0034622	protein coding gene	Chr9:43877630-43890021 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034526	protein coding gene	Chr9:48334273-48345768 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035241	protein coding gene	Chr9:43160755-43172241 (+)
PWK/PhJ	MGP_PWKPhJ_G0033437	protein coding gene	Chr9:42140321-42154110 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033273	protein coding gene	Chr9:43450368-43461621 (+)
WSB/EiJ	MGP_WSBEiJ_G0033845	protein coding gene	Chr9:43187206-43199257 (+)

Human Ortholog

MPZL2, myelin protein zero like 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MPZL2, myelin protein zero like 2
Synonyms

DFNB111, EVA, EVA1
Links

HGNC:3496

NCBI Gene ID: 10205

UniProt: O60487
Chr Location

11q23.3; chr11:118253416-118264536 (-) GRCh38

MGI Vertebrate Homology

Mpzl2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MPZL2
Gene Tree

Mpzl2

Diseases

1 with Mpzl2 mouse models; 1 with human MPZL2 associations

Human Disease

Mouse Models

autosomal recessive nonsyndromic deafness 111

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

15 phenotypes from 3 alleles in 3 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

3
Gene trapped

1
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one null allele exhibit alterations in immune cell percentages in peripheral blood and in spleen. Mice homozygous for a second null allele display impaired hearing with degeneration of outer hair cells and Dieter cells.

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All GO Annotations

9
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

841
Tissues

102
cDNA Data

45
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mpzl2

ZFIN mpzl2b

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All Sequences

50
RefSeq

6
UniProt

5
CCDS

CCDS23126.1

Ensembl

ENSMUSG00000032092 (Evidence)
NCBI Gene

14012

			Length	Strain/Species	Flank
genomic	14012	NCBI Gene Model \| MGI Sequence Detail	13747	C57BL/6J	± kb
transcript	NM_007962	RefSeq \| MGI Sequence Detail	3216	ZRU/MplStud
polypeptide	O70255	UniProt \| EBI \| MGI Sequence Detail	215	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010555 myelin protein zero-like protein 2

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain

IPR000920 Myelin P0 protein-related

IPR029863 Myelin protein zero-like protein 2, Ig-like domain
GlyGen

O70255 2 sites, 1 N-linked glycan (1 site)

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All nucleic 52

cDNA 47

Primer pair 2

Other 3

Microarray probesets 6

Summaries

All 55

Developmental Gene Expression 12

Diseases 1

Gene Ontology 6

Phenotypes 16
Earliest

J:48229 Guttinger M, et al., Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis. J Cell Biol. 1998 May 18;141(4):1061-71
Latest

J:365058 Son YL, et al., Eva1 deficiency prevents obesity-induced metabolic disorders by reducing visceral adipose dysfunction. Metabolism. 2025 Mar 19;168:156235

TSS for Mpzl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84712	Chr9:44951044-44951055 (+)	-545 bp
Tssr84713	Chr9:44951075-44951090 (+)	-512 bp
Tssr84714	Chr9:44951717-44951749 (+)	138 bp
Tssr84715	Chr9:44953833-44953849 (+)	2,246 bp
Tssr84716	Chr9:44953863-44953921 (+)	2,297 bp
Tssr84717	Chr9:44953925-44953958 (+)	2,347 bp
Tssr84718	Chr9:44953961-44953967 (+)	2,369 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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