Mpzl2^em1Shuy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mpzl2^em1Shuy
• Name: myelin protein zero-like 2; endonuclease-mediated mutation 1, Yilai Shu
• MGI ID: MGI:8233581
• Gene: Mpzl2 Location: Chr9:44951595-44965341 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: Mpzl2^em1Shuy page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using two single guide RNAs (TTT ACC TCT AAT TGG CCC TC [PAM:CGG] and AGA TTC TTG TCA CCT TCC AG [PAM: AGG]) targeting exon 2 created a 343 bp deletion. (J:370428)
• Inheritance: Not Specified

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpzl2 Mutation: 18 strains or lines available

References

• Original: J:370428 Jiang L, et al., Hearing restoration by gene replacement therapy for a multisite-expressed gene in a mouse model of human DFNB111 deafness. Am J Hum Genet. 2024 Oct 3;111(10):2253-2264
• All: 1 reference(s)