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Il12rb2 Gene Detail
Summary
  • Symbol
    Il12rb2
  • Name
    interleukin 12 receptor, beta 2
  • Synonyms
    A930027I18Rik, Ifnm, IL-12RB2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270861
    NCBI Gene: 16162
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:67268302-67353172 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 30.81 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    531 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270861
 protein coding gene Chr6:67263914-67353277 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030845
 protein coding gene Chr6:67278925-67375454 (-)
A/J MGP_AJ_G0030815
 protein coding gene Chr6:64378606-64478370 (-)
AKR/J MGP_AKRJ_G0030743
 protein coding gene Chr6:66398811-66484871 (-)
BALB/cJ MGP_BALBcJ_G0030826
 protein coding gene Chr6:64752504-64838638 (-)
C3H/HeJ MGP_C3HHeJ_G0030886
 protein coding gene Chr6:117656898-117742238 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031284
 protein coding gene Chr6:68887565-68980360 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028473
 protein coding gene Chr6:61546292-61628012 (-)
CAST/EiJ MGP_CASTEiJ_G0029934
 protein coding gene Chr6:66686768-66780279 (-)
CBA/J MGP_CBAJ_G0030513
 protein coding gene Chr6:71699889-71798129 (-)
DBA/2J MGP_DBA2J_G0030665
 protein coding gene Chr6:64042397-64133355 (-)
FVB/NJ MGP_FVBNJ_G0030618
 protein coding gene Chr6:63546668-63630469 (-)
LP/J MGP_LPJ_G0030744
 protein coding gene Chr6:67243963-67332695 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030653
 protein coding gene Chr6:75439912-75539211 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031310
 protein coding gene Chr6:66313025-66407865 (-)
PWK/PhJ MGP_PWKPhJ_G0029649
 protein coding gene Chr6:63236472-63322619 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029478
 protein coding gene Chr6:65886960-66028853 (-)
WSB/EiJ MGP_WSBEiJ_G0030016
 protein coding gene Chr6:66648721-66739232 (-)



Homology
more
  • Human Ortholog
    IL12RB2, interleukin 12 receptor subunit beta 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL12RB2, interleukin 12 receptor subunit beta 2
  • Links
    NCBI Gene ID: 3595
    neXtProt AC: NX_Q99665
    UniProt: Q99665

  • Chr Location
    1p31.3; chr1:67307364-67398724 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele have defects in IFN-gamma production and cytotoxic T lymphocyte and NK cytotoxicity, develop an autoimmune/lymphoproliferative disorder associated with higher susceptibility to spontaneous tumor formation, but show reduced in vivo growth of B16 melanoma tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    29
  • cDNA Data
    8
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018341 Ensembl Gene Model | MGI Sequence Detail 84871 C57BL/6J ±  kb
    transcript ENSMUST00000018485 Ensembl | MGI Sequence Detail 2998 Not Applicable  
    polypeptide ENSMUSP00000010605 Ensembl | MGI Sequence Detail 874 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 6
      cDNA 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1924481, MGI:2152339
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 90
    • Earliest
      J:37050 Presky DH, et al., A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14002-7
    • Latest
      J:334156 Hildreth AD, et al., Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production. Cell Rep. 2023 Feb 18;42(2):112141
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory