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Dnmt3b Gene Detail
Summary
  • Symbol
    Dnmt3b
  • Name
    DNA methyltransferase 3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261819
    NCBI Gene: 13436
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:153491370-153529650 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.79 cM, cytoband A2-A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1027 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261819
 protein coding gene Chr2:153491332-153529650 (+)
129S1/SvImJ ENSMUSG00200024515
 protein coding gene Chr2:150406855-150445371 (+)
A/J ENSMUSG00195018694
 protein coding gene Chr2:150687214-150725179 (+)
AKR/J ENSMUSG00220043128
 protein coding gene Chr2:150010617-150048911 (+)
BALB/cJ ENSMUSG00180037838
 protein coding gene Chr2:150173094-150211610 (+)
C3H/HeJ ENSMUSG00175044427
 protein coding gene Chr2:150917312-150955824 (+)
C57BL/6NJ ENSMUSG00215029722
 protein coding gene Chr2:150336478-150374775 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024491
 protein coding gene Chr2:145541539-145580439 (+)
CAST/EiJ ENSTCUG00005040921
 protein coding gene Chr2:149270272-149308881 (+)
CBA/J ENSMUSG00210041329
 protein coding gene Chr2:150853843-150892356 (+)
DBA/2J ENSMUSG00185043571
 protein coding gene Chr2:150516949-150555443 (+)
FVB/NJ ENSMUSG00205025293
 protein coding gene Chr2:149597537-149636064 (+)
JF1/MsJ ENSUMUG00000033485
 protein coding gene Chr2:150175957-150213925 (+)
LP/J ENSMUSG00230035450
 protein coding gene Chr2:152155532-152194046 (+)
NOD/ShiLtJ ENSMUSG00190031167
 protein coding gene Chr2:150274914-150312878 (+)
NZO/HlLtJ ENSMUSG00225004058
 protein coding gene Chr2:160187147-160225441 (+)
PWK/PhJ ENSLUMG00010041104
 protein coding gene Chr2:150148180-150186337 (+)
SPRET/EiJ ENSMSPG00010028391
 protein coding gene Chr2:152868120-152906881 (+)
WSB/EiJ ENSIUOG00005046994
 protein coding gene Chr2:150001790-150040318 (+)



Homology
more
  • Human Ortholog
    DNMT3B, DNA methyltransferase 3 beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNMT3B, DNA methyltransferase 3 beta
  • Synonyms
    FSHD4, ICF, ICF1, M.HsaIIIB
  • Links
    NCBI Gene ID: 1789
    UniProt: Q9UBC3

  • Chr Location
    20q11.21; chr20:32762385-32809359 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dnmt3b mouse models; 12 with human DNMT3B associations

Human Disease Mouse Models
      
IDs
 View 7 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 9 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    98 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit growth retardation and rostral neural tube defects, and die prenatally. Mutants exhibit slight under-methylation of endogenous viral DNA and substantial demethylation of minor satellite DNA.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1853
  • Tissues
    734
  • cDNA Data
    15
  • Literature Summary
    76
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027478 Ensembl Gene Model | MGI Sequence Detail 38281 C57BL/6J ±  kb
    transcript ENSMUST00000056495 Ensembl | MGI Sequence Detail 4318 Not Applicable  
    polypeptide ENSMUSP00000051830 Ensembl | MGI Sequence Detail 860 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 2
      cDNA 15
      Primer pair 30
      Other 1
      Antibodies 13

      Microarray probesets 5
    References
    more
    • Summaries
      All 262
      Developmental Gene Expression 76
      Diseases 2
      Gene Ontology 34
      Phenotypes 98
    • Earliest
      J:48528 Okano M, et al., Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases [letter]. Nat Genet. 1998 Jul;19(3):219-20
    • Latest
      J:378435 Huang Y, et al., Dnmt3b Deficiency in Adipocyte Progenitor Cells Ameliorates Obesity in Female Mice. Int J Mol Sci. 2026 Jan 15;27(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory