About   Help   FAQ
Kcnj8 Gene Detail
Summary
  • Symbol
    Kcnj8
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 8
  • Synonyms
    gnite, Kir6.1, slmbr, sltr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100508
    NCBI Gene: 16523
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:142510563-142517340 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 74.31 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    319 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100508
 protein coding gene Chr6:142510563-142517340 (-)
129S1/SvImJ ENSMUSG00200030227
 protein coding gene Chr6:140051558-140058336 (-)
A/J ENSMUSG00195008080
 protein coding gene Chr6:138957948-138964727 (-)
AKR/J ENSMUSG00220027326
 protein coding gene Chr6:137184866-137191645 (-)
BALB/cJ ENSMUSG00180014936
 protein coding gene Chr6:139085485-139092264 (-)
C3H/HeJ ENSMUSG00175032665
 protein coding gene Chr6:138984814-138991594 (-)
C57BL/6NJ ENSMUSG00215024609
 protein coding gene Chr6:139156008-139162786 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029035
 protein coding gene Chr6:140403536-140410120 (-)
CAST/EiJ ENSTCUG00005036247
 protein coding gene Chr6:139816240-139823016 (-)
CBA/J ENSMUSG00210004815
 protein coding gene Chr6:139047509-139054287 (-)
DBA/2J ENSMUSG00185022705
 protein coding gene Chr6:139698054-139704832 (-)
FVB/NJ ENSMUSG00205026936
 protein coding gene Chr6:138071038-138077847 (-)
JF1/MsJ ENSUMUG00000006234
 protein coding gene Chr6:138353395-138360232 (-)
LP/J ENSMUSG00230009498
 protein coding gene Chr6:140836863-140843695 (-)
NOD/ShiLtJ ENSMUSG00190006007
 protein coding gene Chr6:139521160-139527967 (-)
NZO/HlLtJ ENSMUSG00225013271
 protein coding gene Chr6:143688112-143694890 (-)
PWK/PhJ ENSLUMG00010032091
 protein coding gene Chr6:137436816-137443631 (-)
SPRET/EiJ ENSMSPG00010015994
 protein coding gene Chr6:141350184-141357104 (-)
WSB/EiJ ENSIUOG00005022353
 protein coding gene Chr6:139762943-139769739 (-)



Homology
more
  • Human Ortholog
    KCNJ8, potassium inwardly rectifying channel subfamily J member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNJ8, potassium inwardly rectifying channel subfamily J member 8
  • Synonyms
    KIR6.1, uKATP-1
  • Links
    NCBI Gene ID: 3764
    UniProt: Q15842

  • Chr Location
    12p12.1; chr12:21764950-21775615 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Kcnj8 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 6 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit sudden cardiac death due to dysregulation of the vascular tonus in the coronary arteries, and exhibit a phenotype resembling Prinzmetal (or variant) angina in humans.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    131
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    646
  • Tissues
    42
  • cDNA Data
    30
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16523 NCBI Gene Model | MGI Sequence Detail 6778 C57BL/6J ±  kb
    transcript NM_008428 RefSeq | MGI Sequence Detail 2564 ZRU/MplStud  
    polypeptide P97794 UniProt | EBI | MGI Sequence Detail 424 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000001984 ATP-sensitive inward rectifier potassium channel 8
      (term hierarchy)
    • InterPro Domains
      IPR014756 Immunoglobulin E-set
      IPR041647 Inward rectifier potassium channel, C-terminal
      IPR016449 Potassium channel, inwardly rectifying, Kir
      IPR003278 Potassium channel, inwardly rectifying, Kir6.1
      IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
      IPR040445 Potassium channel, inwardly rectifying, transmembrane domain
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 30
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141411, MGI:3626329, MGI:3626331, MGI:3626333
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 30
      Phenotypes 44
    • Earliest
      J:43481 Isomoto S, et al., Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse chromosome 6. Mamm Genome. 1997 Oct;8(10):790-1
    • Latest
      J:387843 Bowen RM, et al., Control of neurovascular coupling by ATP-sensitive potassium channels. J Cereb Blood Flow Metab. 2025 Jun;45(6):1130-1143
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory