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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Kcnj8
potassium inwardly-rectifying channel, subfamily J, member 8
MGI:1100508
27 phenotypes from 6 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Kcnj8em1Nich/Kcnj8+
involves: C57BL/6J * CBA/J
abnormal aorta morphology J:281903
abnormal channel response J:281903
abnormal heart echocardiography feature J:281903
abnormal heart left ventricle morphology J:281903
abnormal vascular smooth muscle physiology J:281903
aortic arch dilation J:281903
aortic valve regurgitation J:281903
aortic valve stenosis J:281903
cardiac hypertrophy J:281903
decreased survivor rate J:281903
dilated heart left ventricle J:281903
enlarged heart J:281903
hypotension J:281903
increased cardiac output J:281903
increased heart weight J:281903
increased myocardial fiber size J:281903
increased vasodilation J:281903
premature death J:281903
Kcnj8em1Nich/Kcnj8em1Nich
involves: C57BL/6J * CBA/J
abnormal intestine morphology J:281903
premature death J:281903
weight loss J:281903
Kcnj8sos/Kcnj8sos
C57BL/6J-Kcnj8sos
increased susceptibility to endotoxin shock J:149353
Kcnj8tm1Sse/Kcnj8tm1Sse
involves: 129S1/Sv * 129X1/SvJ
abnormal vascular smooth muscle physiology J:202037
hypertension J:202037
Kcnj8tm1Sse/Kcnj8tm1Sse
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal myocardial fiber physiology J:76195
normal cardiovascular system phenotype J:76195
coronary artery spasm J:76195
irregular heartbeat J:76195
premature death J:76195
Tg(ACTB-EGFP,-Kcnj8)1Nich/0
Tg(Myh11-icre/ERT2)1Soff/0
involves: C57BL/6 * CBA * FVB/N
normal cardiovascular system phenotype J:202037
Tg(ACTB-EGFP,-Kcnj8*G343D)9Nich/0
Tg(Myh11-icre/ERT2)1Soff/0
involves: C57BL/6 * CBA * FVB/N
abnormal vascular smooth muscle physiology J:202037
decreased vasoconstriction J:202037
hypotension J:202037
Tg(ACTB-EGFP,-Kcnj8*Q53R*G343D)1Nich/0
Tg(Myh11-icre/ERT2)1Soff/0
involves: C57BL/6 * CBA * FVB/N
hypotension J:202037

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory