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Ywhaz Gene Detail
Summary
  • Symbol
    Ywhaz
  • Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
  • Synonyms
    1110013I11Rik, 14-3-3 zeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:109484
    NCBI Gene: 22631
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:36771014-36797173 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 14.56 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    560 from dbSNP Build 142
  • Strain Annotations
    29
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109484
 protein coding gene Chr15:36770505-36803228 (-)
129S1/SvImJ ENSMUSG00200016156
 protein coding gene Chr17:50943607-50945435 (-)
129S1/SvImJ ENSMUSG00200025528
 protein coding gene Chr15:33781447-33807630 (-)
A/J ENSMUSG00195006501
 protein coding gene Chr17:52342785-52344614 (-)
A/J ENSMUSG00195034489
 protein coding gene Chr15:33709636-33735799 (-)
AKR/J ENSMUSG00220012249
 protein coding gene Chr17:51386514-51387660 (-)
AKR/J ENSMUSG00220025819
 protein coding gene Chr15:33623564-33647347 (-)
BALB/cJ ENSMUSG00180005957
 protein coding gene Chr17:52100390-52102196 (-)
BALB/cJ ENSMUSG00180030242
 protein coding gene Chr15:33671776-33697937 (-)
C3H/HeJ ENSMUSG00175006631
 protein coding gene Chr17:51403306-51405135 (-)
C3H/HeJ ENSMUSG00175024822
 protein coding gene Chr15:33876068-33899845 (-)
C57BL/6NJ ENSMUSG00215017472
 protein coding gene Chr15:33683908-33707686 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019741
 protein coding gene Chr15:31667157-31691303 (-)
CAST/EiJ ENSTCUG00005009867
 protein coding gene Chr15:33713189-33736990 (-)
CBA/J ENSMUSG00210017692
 protein coding gene Chr15:33790501-33814278 (-)
CBA/J ENSMUSG00210026965
 protein coding gene Chr17:51183539-51185368 (-)
DBA/2J ENSMUSG00185008496
 protein coding gene Chr17:54053422-54055251 (-)
DBA/2J ENSMUSG00185031804
 protein coding gene Chr15:33771342-33797501 (-)
FVB/NJ ENSMUSG00205006689
 protein coding gene Chr17:51725323-51727141 (-)
FVB/NJ ENSMUSG00205023112
 protein coding gene Chr15:33681156-33707318 (-)
JF1/MsJ ENSUMUG00000028570
 protein coding gene Chr15:33657664-33683845 (-)
LP/J ENSMUSG00230011764
 protein coding gene Chr15:37162661-37188842 (-)
LP/J ENSMUSG00230025714
 protein coding gene Chr17:55021052-55022880 (-)
NOD/ShiLtJ ENSMUSG00190009529
 protein coding gene Chr17:51177800-51179630 (-)
NOD/ShiLtJ ENSMUSG00190030089
 protein coding gene Chr15:33752618-33778777 (-)
NZO/HlLtJ ENSMUSG00225031494
 protein coding gene Chr15:37462818-37488977 (-)
PWK/PhJ ENSLUMG00010030911
 protein coding gene Chr15:33833568-33859749 (-)
SPRET/EiJ ENSMSPG00010011852
 protein coding gene Chr15:34470827-34496870 (-)
WSB/EiJ ENSIUOG00005031560
 protein coding gene Chr15:33793213-33819373 (-)



Homology
more
  • Human Ortholog
    YWHAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YWHAZ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  • Synonyms
    14-3-3-zeta, HEL4, HEL-S-3, HEL-S-93, KCIP-1, POPCHAS, YWHAD
  • Links
    NCBI Gene ID: 7534
    UniProt: P63104

  • Chr Location
    8q22.3; chr8:100916523-100953388 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ywhaz mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit growth retardation after P14, some postnatal lethality by P21. Mice homozygous for one gene trap allele also exhibit neurodevelopmental and neuropsychiatric behaviour defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    100
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    86
  • cDNA Data
    26
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022285 Ensembl Gene Model | MGI Sequence Detail 26160 C57BL/6J ±  kb
    transcript ENSMUST00000110362 Ensembl | MGI Sequence Detail 2122 Not Applicable  
    polypeptide ENSMUSP00000105991 Ensembl | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 28
      Primer pair 5
      Other 3
      Antibodies 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-39483, MGI:1915893, MGI:2146042, MGI:2146113, MGI:2146160
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 24
      Phenotypes 35
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:378933 Boulan B, et al., Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species. Sci Adv. 2026 Feb 6;12(6):eadz6827
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory