Itga8 MGI Mouse Gene Detail - MGI:109442

Symbol

Itga8
Name

integrin alpha 8

Feature Type

protein coding gene
IDs

MGI:109442
NCBI Gene: 241226
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:12111443-12306733 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 9.12 cM
Mapping Data

1 experiment

SNPs within 2kb

6258 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109442	protein coding gene	Chr2:12111443-12306755 (-)
129S1/SvImJ	ENSMUSG00200030134	protein coding gene	Chr2:9005585-9201178 (-)
A/J	ENSMUSG00195016997	protein coding gene	Chr2:9130801-9326483 (-)
AKR/J	ENSMUSG00220005911	protein coding gene	Chr2:9095786-9291430 (-)
BALB/cJ	ENSMUSG00180030743	protein coding gene	Chr2:9180633-9376282 (-)
C3H/HeJ	ENSMUSG00175016538	protein coding gene	Chr2:9114952-9310603 (-)
C57BL/6NJ	ENSMUSG00215009443	protein coding gene	Chr2:9194829-9390495 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023180	protein coding gene	Chr2:8676245-8866635 (-)
CAST/EiJ	ENSTCUG00005004336	protein coding gene	Chr2:8978996-9174539 (-)
CBA/J	ENSMUSG00210026665	protein coding gene	Chr2:9160964-9356600 (-)
DBA/2J	ENSMUSG00185012257	protein coding gene	Chr2:9075917-9271569 (-)
FVB/NJ	ENSMUSG00205027388	protein coding gene	Chr2:9066248-9261884 (-)
JF1/MsJ	ENSUMUG00000003050	protein coding gene	Chr2:9022595-9215623 (-)
LP/J	ENSMUSG00230016239	protein coding gene	Chr2:11017871-11213519 (-)
NOD/ShiLtJ	ENSMUSG00190005866	protein coding gene	Chr2:9117819-9313786 (-)
NZO/HlLtJ	ENSMUSG00225001245	protein coding gene	Chr2:18768023-18963652 (-)
PWK/PhJ	ENSLUMG00010027870	protein coding gene	Chr2:9132450-9325974 (-)
SPRET/EiJ	ENSMSPG00010026741	protein coding gene	Chr2:9266191-9463336 (-)
WSB/EiJ	ENSIUOG00005022413	protein coding gene	Chr2:9151940-9349239 (-)

Human Ortholog

ITGA8, integrin subunit alpha 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITGA8, integrin subunit alpha 8
Links

HGNC:6144

NCBI Gene ID: 8516

UniProt: P53708
Chr Location

10p13; chr10:15513954-15719936 (-) GRCh38

MGI Vertebrate Homology

Itga8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ITGA8
Gene Tree

Itga8

Diseases

4 with human ITGA8 associations

				Human Disease	Mouse Models
				end stage renal disease IDs end stage renal disease DOID:783
				ovarian cancer IDs ovarian cancer DOID:2394 DOID:0060070 DOID:2144 DOID:9595 ICD10CM:C56 ICD9CM:183.0 MESH:D010051 NCI:C4984 NCI:C7431 OMIM:167000 OMIM:607893 ORDO:213500 ORDO:213517 UMLS_CUI:C0919267 UMLS_CUI:C1140680 UMLS_CUI:C1299247
				renal agenesis IDs renal agenesis DOID:14766 MESH:C563261 OMIM:191830 ORDO:93108
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

36 phenotypes from 3 alleles in 3 genetic backgrounds
6 phenotypes from multigenic genotypes
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

6
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

76 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for disruptions in this gene usually die by the end of the second day after birth. Those that do survive have reduced kidneys and abnormal steriocilia in the inner ear.

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All GO Annotations

45
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

849
Tissues

81
cDNA Data

49
Literature Summary

57

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase itga8

ZFIN itga8

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All Sequences

55
RefSeq

11
UniProt

3
CCDS

CCDS15689.1

Ensembl

ENSMUSG00000026768 (Evidence)
NCBI Gene

241226

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026768	Ensembl Gene Model \| MGI Sequence Detail	195291	C57BL/6J	± kb
transcript	ENSMUST00000028106	Ensembl \| MGI Sequence Detail	5812	Not Applicable
polypeptide	ENSMUSP00000028106	Ensembl \| MGI Sequence Detail	1062	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009133 integrin alpha-8

(term hierarchy)
InterPro Domains

IPR013517 FG-GAP repeat

IPR013519 Integrin alpha beta-propellor

IPR000413 Integrin alpha chain

IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

IPR013649 Integrin alpha, first immunoglubulin-like domain

IPR028994 Integrin alpha, N-terminal

IPR048285 Integrin alpha, second immunoglobulin-like domain

IPR048286 Integrin alpha, third immunoglobulin-like domain

IPR032695 Integrin domain superfamily
GlyGen

A2ARA8 16 sites, 5 N-linked glycans (7 sites)

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All nucleic 58

Genomic 1

cDNA 49

Primer pair 7

Other 1

Antibodies 6

Microarray probesets 5

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MGD-MRK-38487, MGI:2138946

Summaries

All 114

Developmental Gene Expression 57

Gene Ontology 11

Phenotypes 30
Earliest

J:38838 Muller U, et al., Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell. 1997 Mar 7;88(5):603-13
Latest

J:388029 Garis MR, et al., Nephronectin Promotes Migration of the Periocular Mesenchyme via EGFR Signaling. Invest Ophthalmol Vis Sci. 2026 Jun 1;67(6):40

TSS for Itga8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22668	Chr2:12306807-12306816 (-)	-79 bp
Tssr22667	Chr2:12306799-12306802 (-)	-68 bp
Tssr22666	Chr2:12306745-12306798 (-)	-39 bp
Tssr22665	Chr2:12306725-12306733 (-)	4 bp
Tssr22664	Chr2:12306705-12306714 (-)	23 bp
Tssr22663	Chr2:12305861-12305906 (-)	849 bp
Tssr22662	Chr2:12133346-12133363 (-)	173,378 bp
Tssr22661	Chr2:12115930-12115935 (-)	190,800 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24