Itga8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Itga8
integrin alpha 8
MGI:109442

37 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Itga8^tm1.1Rdav/Itga8^tm1.1Rdav Tg(Camk2a-cre)#Szi/0 involves: 129S6/SvEvTac * C57BL/6J * CBA	normal behavior/neurological phenotype	J:170959
	impaired synaptic plasticity	J:170959
	reduced long-term potentiation	J:170959
Itga8^{tm1b(KOMP)Wtsi}/Itga8⁺ C57BL/6N-Itga8^{tm1b(KOMP)Wtsi}/J	decreased circulating glucose level	J:211773
	decreased mean corpuscular hemoglobin concentration	J:211773
	increased circulating calcium level	J:211773
	increased circulating free fatty acids level	J:211773
	increased circulating sodium level	J:211773
	increased grip strength	J:211773
	increased heart weight	J:211773
	increased mean corpuscular volume	J:211773
Itga8^{tm1b(KOMP)Wtsi}/Itga8^{tm1b(KOMP)Wtsi} C57BL/6N-Itga8^{tm1b(KOMP)Wtsi}/J	preweaning lethality, incomplete penetrance	J:211773
Itga8^tm1Lfr/Itga8⁺ involves: 129X1/SvJ * C57BL/6	normal renal/urinary system phenotype	J:122519
Itga8^tm1Lfr/Itga8^tm1Lfr involves: 129X1/SvJ * C57BL/6	abnormal branching involved in lung morphogenesis	J:154459
	abnormal cell adhesion	J:154459
	abnormal cell migration	J:154459
	abnormal kidney development	J:38838, J:122519
	abnormal kidney morphology	J:38838
	abnormal lung saccule morphology	J:154459
	abnormal motor coordination/balance	J:61486
	abnormal pulmonary elastic fiber morphology	J:154459
	abnormal ureter development	J:38838
	abnormal ureter morphology	J:38838
	abnormal ureteric bud invasion	J:61486
	abnormal vestibular hair cell stereociliary bundle morphology	J:61486
	absent kidney	J:38838, J:122519
	absent ureter	J:38838
	adhesive atelectasis	J:154459
	decreased vestibular hair cell stereocilia number	J:61486
	dilated respiratory conducting tube	J:154459
	fused right lung lobes	J:154459
	fused vestibular hair cell stereocilia	J:61486
	impaired branching involved in ureteric bud morphogenesis	J:61486
	impaired lung lobe morphogenesis	J:154459
	postnatal lethality, incomplete penetrance	J:38838, J:154459
	single kidney	J:38838
	small kidney	J:38838

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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