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Pea15a Gene Detail
Summary
  • Symbol
    Pea15a
  • Name
    proliferation and apoptosis adaptor protein 15A
  • Synonyms
    Mat1, Pea15, PEA-15, PED, phosphoprotein enriched in astrocytes 15A, Pkcs15
  • Feature Type
    protein coding gene
  • IDs
    MGI:104799
    NCBI Gene: 18611
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:172024295-172034371 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.54 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104799
 protein coding gene Chr1:172024295-172034371 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016780
 protein coding gene Chr1:178054539-178064562 (-)
A/J MGP_AJ_G0016759
 protein coding gene Chr1:170764985-170774979 (-)
AKR/J MGP_AKRJ_G0016725
 protein coding gene Chr1:175927216-175937244 (-)
BALB/cJ MGP_BALBcJ_G0016720
 protein coding gene Chr1:171311740-171321767 (-)
C3H/HeJ MGP_C3HHeJ_G0016544
 protein coding gene Chr1:176499819-176509844 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017182
 protein coding gene Chr1:183962627-183972693 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014888
 protein coding gene Chr1:162469905-162479861 (-)
CAST/EiJ MGP_CASTEiJ_G0016124
 protein coding gene Chr1:175860068-175869822 (-)
CBA/J MGP_CBAJ_G0016518
 protein coding gene Chr1:190515883-190525930 (-)
DBA/2J MGP_DBA2J_G0016625
 protein coding gene Chr1:169701847-169711894 (-)
FVB/NJ MGP_FVBNJ_G0016622
 protein coding gene Chr1:167957984-167967981 (-)
LP/J MGP_LPJ_G0016696
 protein coding gene Chr1:179146253-179156278 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016649
 protein coding gene Chr1:197761853-197771890 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017218
 protein coding gene Chr1:175794723-175804741 (-)
PWK/PhJ MGP_PWKPhJ_G0015910
 protein coding gene Chr1:169076843-169087231 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015692
 protein coding gene Chr1:174745519-174755493 (-)
WSB/EiJ MGP_WSBEiJ_G0016186
 protein coding gene Chr1:175949938-175960878 (-)



Homology
more
  • Human Ortholog
    PEA15, proliferation and apoptosis adaptor protein 15
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEA15, proliferation and apoptosis adaptor protein 15
  • Synonyms
    HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, PED-PEA15, PED/PEA15
  • Links
    NCBI Gene ID: 8682
    neXtProt AC: NX_Q15121
    UniProt: Q15121

  • Chr Location
    1q23.2; chr1:160205319-160215376 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit reduced body weight. Although Tnfa-induced apoptosis was increased in astrocytes in vitro, glial cell and brain morphology is normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    45
  • cDNA Data
    287
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18611 NCBI Gene Model | MGI Sequence Detail 10077 C57BL/6J ±  kb
    transcript NM_001420462 RefSeq | MGI Sequence Detail 2647 C57BL/6  
    polypeptide Q62048 UniProt | EBI | MGI Sequence Detail 130 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 314
      Genomic 25
      cDNA 287
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-25622, MGD-MRK-27038, MGD-MRK-28091, MGI:104675
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:20993 Bera TK, et al., Identification of a mammary transforming gene (MAT1) associated with mouse mammary carcinogenesis. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9789-93
    • Latest
      J:304960 Verschoor PJ, et al., Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion. Sci Rep. 2021 Mar 26;11(1):6949
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    05/09/2023
    MGI 6.22     		The Jackson Laboratory