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Relb Gene Detail
Summary
  • Symbol
    Relb
  • Name
    avian reticuloendotheliosis viral (v-rel) oncogene related B
  • Synonyms
    shep
  • Feature Type
    protein coding gene
  • IDs
    MGI:103289
    NCBI Gene: 19698
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19340142-19363352 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103289
 protein coding gene Chr7:19340142-19363363 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031787
 protein coding gene Chr7:17638627-17661808 (-)
A/J MGP_AJ_G0031763
 protein coding gene Chr7:17255594-17278735 (-)
AKR/J MGP_AKRJ_G0031689
 protein coding gene Chr7:17735395-17758482 (-)
BALB/cJ MGP_BALBcJ_G0031768
 protein coding gene Chr7:17461588-17485465 (-)
C3H/HeJ MGP_C3HHeJ_G0031490
 protein coding gene Chr7:17997718-18021930 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032234
 protein coding gene Chr7:18504707-18532383 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029300
 protein coding gene Chr7:18901902-18926548 (-)
CAST/EiJ MGP_CASTEiJ_G0030824
 protein coding gene Chr7:14216699-14454829 (-)
CBA/J MGP_CBAJ_G0031452
 protein coding gene Chr7:19179181-19208420 (-)
DBA/2J MGP_DBA2J_G0031607
 protein coding gene Chr7:17206171-17229858 (-)
FVB/NJ MGP_FVBNJ_G0031559
 protein coding gene Chr7:17069942-17095290 (-)
LP/J MGP_LPJ_G0031690
 protein coding gene Chr7:17955494-17978556 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031595
 protein coding gene Chr7:19010478-19036952 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032262
 protein coding gene Chr7:17340870-17365075 (-)
PWK/PhJ MGP_PWKPhJ_G0030557
 protein coding gene Chr7:14302731-14326789 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030384
 protein coding gene Chr7:12045912-12076921 (-)
WSB/EiJ MGP_WSBEiJ_G0030933
 protein coding gene Chr7:17561198-17585463 (-)



Homology
more
  • Human Ortholog
    RELB, RELB proto-oncogene, NF-kB subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RELB, RELB proto-oncogene, NF-kB subunit
  • Synonyms
    IMD53, IREL, I-REL, REL-B
  • Links
    NCBI Gene ID: 5971
    neXtProt AC: NX_Q01201
    UniProt: Q01201

  • Chr Location
    19q13.32; chr19:45001461-45038192 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Relb mouse models; 2 with human RELB associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    88 phenotypes from 3 alleles in 6 genetic backgrounds
    33 phenotypes from multigenic genotypes
    3 images
    105 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant homozygotes die prematurely with phenotypes including inflammatory cell infiltration of organs, myeloid hyperplasia, splenomegaly, reduction in thymic dendritic cells, impaired cellular immunity, hyperkeratosis, epidermal hyperplasia, or hepatitiswith mononuclear infiltration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    47
  • cDNA Data
    41
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19698 NCBI Gene Model | MGI Sequence Detail 23211 C57BL/6J ±  kb
    transcript NM_001417184 RefSeq | MGI Sequence Detail 4449 ZRU/MplStud  
    polypeptide Q04863 UniProt | EBI | MGI Sequence Detail 558 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 3
      cDNA 41
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24171, MGI:4838325
    References
    more
    • Summaries
      All 203
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 18
      Phenotypes 105
    • Earliest
      J:22332 Ryseck RP, et al., RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B. Mol Cell Biol. 1992 Feb;12(2):674-84
    • Latest
      J:339973 Navarro HI, et al., RelB-deficient autoinflammatory pathology presents as interferonopathy, but in mice is interferon-independent. J Allergy Clin Immunol. 2023 Jul 15;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory