Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in non-canonical NF-kappaB signal transduction and regulation of gene expression. Acts upstream of or within T-helper 1 cell differentiation; antigen processing and presentation; and myeloid dendritic cell differentiation. Located in cytosol and nucleus. Is active in synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and lung. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in breast cancer and immunodeficiency 53. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit).