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Nqo1 Gene Detail
Summary
  • Symbol
    Nqo1
  • Name
    NAD(P)H dehydrogenase, quinone 1
  • Synonyms
    Dia4, NAD(P)H dehydrogenase (quinone), NMO1, Nmor1, NQO1, Ox1, Ox-1, QR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103187
    NCBI Gene: 18104
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:108114857-108129838 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 54.08 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    528 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103187
protein coding gene Chr8:108114856-108139012 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034100
protein coding gene Chr8:109844405-109859363 (-)
A/J MGP_AJ_G0034080
protein coding gene Chr8:105421030-105436060 (-)
AKR/J MGP_AKRJ_G0034006
protein coding gene Chr8:108497663-108512649 (-)
BALB/cJ MGP_BALBcJ_G0034073
protein coding gene Chr8:105629635-105644642 (-)
C3H/HeJ MGP_C3HHeJ_G0033785
protein coding gene Chr8:109226305-109241089 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034593
protein coding gene Chr8:113828429-113843415 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031535
protein coding gene Chr8:98518896-98533856 (-)
CAST/EiJ MGP_CASTEiJ_G0033112
protein coding gene Chr8:108767207-108784526 (-)
CBA/J MGP_CBAJ_G0033758
protein coding gene Chr8:117528381-117543421 (-)
DBA/2J MGP_DBA2J_G0033913
protein coding gene Chr8:104749308-104764348 (-)
FVB/NJ MGP_FVBNJ_G0033858
protein coding gene Chr8:103693925-103708723 (-)
LP/J MGP_LPJ_G0034004
protein coding gene Chr8:110029289-110045814 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033903
protein coding gene Chr8:120671495-120687251 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034611
protein coding gene Chr8:108438586-108455009 (-)
PWK/PhJ MGP_PWKPhJ_G0032814
protein coding gene Chr8:104170361-104186984 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032653
protein coding gene Chr8:107145915-107170116 (-)
WSB/EiJ MGP_WSBEiJ_G0033227
protein coding gene Chr8:109153769-109168951 (-)



Homology
more
  • Human Ortholog
    NQO1, NAD(P)H quinone dehydrogenase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NQO1, NAD(P)H quinone dehydrogenase 1
  • Synonyms
    DHQU, DIA4, DTD, NMOR1, NMORI, QR1
  • Links
    NCBI Gene ID: 1728
    neXtProt AC: NX_P15559
    UniProt: P15559

  • Chr Location
    16q22.1; chr16:69706996-69726668 (-)  GRCh38

Human Diseases
more
  • Diseases
    13 with human NQO1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted null mice display increased toxicity to menadione, insulin resistance, an altered intracellular redox status, as well as decreased pyridine nucleotide synthesis, gluconeogenesis and fatty acid metabolism, leading to reduced quantities of abdominal adipose tissue.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003849 Ensembl Gene Model | MGI Sequence Detail 14982 C57BL/6J ±  kb
    transcript ENSMUST00000003947 Ensembl | MGI Sequence Detail 1553 Not Applicable  
    polypeptide ENSMUSP00000003947 Ensembl | MGI Sequence Detail 274 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 1
      cDNA 34
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13090, MGD-MRK-13092, MGD-MRK-19559, MGD-MRK-24055, MGI:2142727
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 32
      Gene Ontology 12
      Phenotypes 44
    • Earliest
      J:5757 Kumaki K, et al., Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse. J Biol Chem. 1977 Jan 10;252(1):157-65
    • Latest
      J:341977 Wang TX, et al., Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis. Life Sci Alliance. 2023 Jan;6(1):e202201667

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    07/05/2024
    MGI 6.24
    The Jackson Laboratory