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Nfatc2 Gene Detail
Summary
  • Symbol
    Nfatc2
  • Name
    nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
  • Synonyms
    NFAT1, NFAT1-D, NFATp
  • Feature Type
    protein coding gene
  • IDs
    MGI:102463
    NCBI Gene: 18019
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:168318330-168443577 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 88.91 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    825 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102463
protein coding gene Chr2:168318330-168443900 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026927
protein coding gene Chr2:174329391-174457165 (-)
A/J MGP_AJ_G0026894
protein coding gene Chr2:167112822-167238500 (-)
AKR/J MGP_AKRJ_G0026865
protein coding gene Chr2:172104974-172234193 (-)
BALB/cJ MGP_BALBcJ_G0026903
protein coding gene Chr2:167473584-167599082 (-)
C3H/HeJ MGP_C3HHeJ_G0026645
protein coding gene Chr2:172469757-172598627 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027350
protein coding gene Chr2:179403832-179530698 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024721
protein coding gene Chr2:160421889-160548605 (-)
CAST/EiJ MGP_CASTEiJ_G0026103
protein coding gene Chr2:172962986-173095672 (-)
CBA/J MGP_CBAJ_G0026622
protein coding gene Chr2:186000548-186140028 (-)
DBA/2J MGP_DBA2J_G0026760
protein coding gene Chr2:166213336-166339251 (-)
FVB/NJ MGP_FVBNJ_G0026726
protein coding gene Chr2:164784183-164915553 (-)
LP/J MGP_LPJ_G0026861
protein coding gene Chr2:174336174-174467056 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026745
protein coding gene Chr2:189299928-189425597 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027407
protein coding gene Chr2:172033966-172162605 (-)
PWK/PhJ MGP_PWKPhJ_G0025840
protein coding gene Chr2:165907358-166035569 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025641
protein coding gene Chr2:170999669-171132825 (-)
WSB/EiJ MGP_WSBEiJ_G0026176
protein coding gene Chr2:172948071-173076220 (-)



Homology
more
  • Human Ortholog
    NFATC2, nuclear factor of activated T cells 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFATC2, nuclear factor of activated T cells 2
  • Synonyms
    JCOSL, NFAT1, NFATP
  • Links
    NCBI Gene ID: 4773
    neXtProt AC: NX_Q13469
    UniProt: Q13469

  • Chr Location
    20q13.2; chr20:51386957-51562839 (-)  GRCh38

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 6 alleles in 8 genetic backgrounds
    28 phenotypes from multigenic genotypes
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this locus cause altered immune system function such as decreased cytokine production by mast cells, increased Th2 responses after infection with a parasite but decreased Th1 responses after myobacterial infection, retarded thymic involutionand massive germinal center formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027544 Ensembl Gene Model | MGI Sequence Detail 125248 C57BL/6J ±  kb
    transcript ENSMUST00000074618 Ensembl | MGI Sequence Detail 6637 Not Applicable  
    polypeptide ENSMUSP00000074198 Ensembl | MGI Sequence Detail 927 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      17 Sequences
    • Protein Ontology
      PR:000011164 nuclear factor of activated T-cells, cytoplasmic 2
    • InterPro Domains
      IPR014756 Immunoglobulin E-set
      IPR013783 Immunoglobulin-like fold
      IPR002909 IPT domain
      IPR008366 Nuclear factor of activated T cells (NFAT)
      IPR008967 p53-like transcription factor, DNA-binding domain superfamily
      IPR032397 Rel homology dimerisation domain
      IPR011539 Rel homology domain, DNA-binding domain
      IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 4
      cDNA 40
      Primer pair 4
      Other 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-12824, MGD-MRK-19300, MGI:2139019
    References
    more
    • Summaries
      All 214
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 38
      Phenotypes 91
    • Earliest
      J:15443 McCaffrey PG, et al., Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science. 1993 Oct 29;262(5134):750-4
    • Latest
      J:346703 Bulow S, et al., Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response. Cell Rep. 2024 Mar 26;43(3):113929

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/21/2024
    MGI 6.23
    The Jackson Laboratory