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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfatc2
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
MGI:102463
39 phenotypes from 6 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0
involves: BALB/cJ 		abnormal hematopoietic system morphology/development J:148341
prenatal lethality, incomplete penetrance J:148341
Gt(ROSA)26Sortm1(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		abnormal interferon level J:148341
abnormal T cell activation J:148341
Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0
involves: BALB/cJ 		abnormal hematopoietic system morphology/development J:148341
prenatal lethality, incomplete penetrance J:148341
Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		abnormal interferon level J:148341
abnormal T cell activation J:148341
Nfatc2m1Anu/Nfatc2m1Anu
C57BL/6NCrlAnu-Nfatc2m1Anu 		normal immune system phenotype J:104190
Nfatc2tm1Glm/Nfatc2tm1Glm
Not Specified 		normal craniofacial phenotype J:118753
Nfatc2tm1Rao/Nfatc2tm1Rao
B6.Cg-Nfatc2tm1Rao 		abnormal mast cell physiology J:78089
decreased interleukin-4 secretion J:78089
decreased interleukin-13 secretion J:78089
decreased tumor necrosis factor secretion J:78089
Nfatc2tm1Srf/Nfatc2tm1Srf
B6.Cg-Nfatc2tm1Srf 		abnormal CD4-positive, alpha-beta T cell physiology J:86279
abnormal T-helper 1 physiology J:86279
abnormal T-helper 2 physiology J:86279
decreased interferon-gamma secretion J:86279
increased IgE level J:86279
increased IgG1 level J:86279
increased immunoglobulin level J:86279
increased interleukin-4 secretion J:86279
increased interleukin-5 secretion J:86279
Nfatc2tm1Srf/Nfatc2tm1Srf
involves: 129P2/OlaHsd 		abnormal immune system organ morphology J:45252
abnormal immune system physiology J:45252
abnormal interleukin secretion J:45252
abnormal lymph node morphology J:45252
abnormal T cell physiology J:45252
enlarged lymph nodes J:45252
enlarged spleen J:45252
increased B cell number J:45252
increased lymphocyte cell number J:45252
increased T cell number J:45252
lymph node hyperplasia J:45252
Nfatc2tm1Srf/Nfatc2tm1Srf
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell number J:110686
abnormal B cell physiology J:110686
abnormal lymph node B cell domain morphology J:110686
abnormal lymphocyte physiology J:110686
abnormal spleen germinal center morphology J:110686
abnormal T cell physiology J:110686
abnormal thymus involution J:110686
enlarged spleen J:110686
enlarged thymus J:110686
increased activated T cell number J:110686
thymus hyperplasia J:110686
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory