Tbp MGI Mouse Gene Detail - MGI:101838 - TATA box binding protein

About Help FAQ

Tbp Gene Detail

Symbol

Tbp
Name

TATA box binding protein
Synonyms

Gtf2d

Feature Type

protein coding gene
IDs

MGI:101838
NCBI Gene: 21374
Alliance

genome feature page
Transcription Start Sites

3 TSS
Candidate for QTL

3 QTL

more

Sequence Map

Chr17:15720150-15737689 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.95 cM
Mapping Data

14 experiments

more

SNPs within 2kb

356 from dbSNP Build 142
Strain Annotations

19
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_101838	protein coding gene	Chr17:15720150-15748641 (+)
129S1/SvImJ	ENSMUSG00200036971	protein coding gene	Chr17:11326950-11355451 (+)
A/J	ENSMUSG00195033456	protein coding gene	Chr17:12084354-12112854 (+)
AKR/J	ENSMUSG00220023123	protein coding gene	Chr17:11745576-11774077 (+)
BALB/cJ	ENSMUSG00180016767	protein coding gene	Chr17:11324795-11353299 (+)
C3H/HeJ	ENSMUSG00175040512	protein coding gene	Chr17:11216396-11245462 (+)
C57BL/6NJ	ENSMUSG00215040707	protein coding gene	Chr17:11428165-11456659 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021096	protein coding gene	Chr17:11107681-11137371 (+)
CAST/EiJ	ENSTCUG00005021218	protein coding gene	Chr17:11749057-11777947 (+)
CBA/J	ENSMUSG00210029364	protein coding gene	Chr17:11060517-11089586 (+)
DBA/2J	ENSMUSG00185037606	protein coding gene	Chr17:13052998-13081504 (+)
FVB/NJ	ENSMUSG00205031601	protein coding gene	Chr17:11739103-11767601 (+)
JF1/MsJ	ENSUMUG00000016439	protein coding gene	Chr17:12627175-12656253 (+)
LP/J	ENSMUSG00230024048	protein coding gene	Chr17:14451239-14479739 (+)
NOD/ShiLtJ	ENSMUSG00190036673	protein coding gene	Chr17:11483037-11512011 (+)
NZO/HlLtJ	ENSMUSG00225046340	protein coding gene	Chr17:16404812-16433312 (+)
PWK/PhJ	ENSLUMG00010020152	protein coding gene	Chr17:11329582-11358640 (+)
SPRET/EiJ	ENSMSPG00010038068	protein coding gene	Chr17:12631646-12660645 (+)
WSB/EiJ	ENSIUOG00005037465	protein coding gene	Chr17:12073910-12102875 (+)

more

Human Ortholog

TBP, TATA-box binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBP, TATA-box binding protein
Synonyms

GTF2D, GTF2D1, HDL4, SCA17, TBP1, TFIID
Links

HGNC:11588

NCBI Gene ID: 6908

UniProt: P20226
Chr Location

6q27; chr6:170554302-170572870 (+) GRCh38

MGI Vertebrate Homology

Tbp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBP
Gene Tree

Tbp

more

Diseases

1 with Tbp mouse models; 4 with human TBP associations

Human Disease

Mouse Models

Human and Mouse genes associated with disease

Human and Mouse genes associated with disease

spinocerebellar ataxia 17

IDs

View 1 model

Human gene associated with disease

late onset Parkinson's disease

IDs

IDs

type 1 diabetes mellitus

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

less

Phenotype Summary

24 phenotypes from 3 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

2
Gene trapped

5
Targeted

8
Incidental Mutations

CvDC
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one null allele exhibit embryonic lethality caused by hemorrhaging and clotting in the placenta and surviving embryos die prior to weaning. Mice homozygous for another null allele undergo growth arrest after hatching and apoptosis.

less

All GO Annotations

107
GO References

33

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

870
Tissues

206
cDNA Data

19
Literature Summary

52

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TBP

Xenbase tbp

ZFIN tbp

less

All Sequences

66
RefSeq

2
UniProt

10
CCDS

CCDS37454.2

Ensembl

ENSMUSG00000014767 (Evidence)
NCBI Gene

21374

Representative Sequences				Length	Strain/Species	Flank
	genomic	21374	NCBI Gene Model \| MGI Sequence Detail	17540	C57BL/6J	± kb
	transcript	NM_013684	RefSeq \| MGI Sequence Detail	1842	ZRU/MplStud
	polypeptide	P29037	UniProt \| EBI \| MGI Sequence Detail	316	Not Applicable

less

UniProt

10 Sequences
Protein Ontology

PR:000016137 TATA-box-binding protein

(term hierarchy)
InterPro Domains

IPR000814 TATA-box binding protein

IPR030491 TATA-box binding protein, conserved site

IPR033710 TATA-box binding protein, eukaryotic

IPR012295 TBP domain superfamily
GlyGen

P29037 3 sites, 1 O-linked glycan (1 site)

less

All nucleic 48

Genomic 13

cDNA 21

Primer pair 12

Other 2

Antibodies 6

Microarray probesets 3

less

MGD-MRK-18659, MGD-MRK-24009

more

Summaries

All 161

Developmental Gene Expression 52

Diseases 1

Gene Ontology 33

Phenotypes 20
Earliest

J:21431 Tamura T, et al., Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID). Nucleic Acids Res. 1991 Jul 25;19(14):3861-5
Latest

J:385405 Hermant C, et al., TBP regulates transposable element expression in early mouse embryos. EMBO J. 2026 May;45(9):3073-3101

TSS for Tbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142753	Chr17:15720170-15720221 (+)	46 bp
Tssr142754	Chr17:15720223-15720238 (+)	81 bp
Tssr142755	Chr17:15720406-15720445 (+)	276 bp

Tbp is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Insq5	Chr17, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 17, Tbp (8.25 cM) shows differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Obq4 (4 cM) maps near candidate gene Tbp. Vegfa (28 cM) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTL Trbv4c1 (23 cM) maps near candidate gene Vegfa. Ppm1b (50.8 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Insq5 (56.7 cM) maps near candidate gene Ppm1b.
Obq4	Chr17, 4.92 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 17, Tbp (8.25 cM) shows differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Obq4 (4 cM) maps near candidate gene Tbp. Vegfa (28 cM) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTL Trbv4c1 (23 cM) maps near candidate gene Vegfa. Ppm1b (50.8 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Insq5 (56.7 cM) maps near candidate gene Ppm1b.
Trbv4c1	Chr17, 20.67 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 17, Tbp (8.25 cM) shows differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Obq4 (4 cM) maps near candidate gene Tbp. Vegfa (28 cM) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTL Trbv4c1 (23 cM) maps near candidate gene Vegfa. Ppm1b (50.8 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Insq5 (56.7 cM) maps near candidate gene Ppm1b.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24