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Bax Gene Detail
Summary
  • Symbol
    Bax
  • Name
    BCL2-associated X protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:99702
    NCBI Gene: 12028
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45111121-45116322 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.32 cM, cytoband B5
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99702
 protein coding gene Chr7:45111121-45116332 (-)
129S1/SvImJ ENSMUSG00200023577
 protein coding gene Chr7:32707719-32712918 (-)
A/J ENSMUSG00195038571
 protein coding gene Chr7:36738678-36743877 (-)
AKR/J ENSMUSG00220008320
 protein coding gene Chr7:31040348-31045549 (-)
BALB/cJ ENSMUSG00180031077
 protein coding gene Chr7:33614101-33619300 (-)
C3H/HeJ ENSMUSG00175025542
 protein coding gene Chr7:34143640-34148839 (-)
C57BL/6NJ ENSMUSG00215039397
 protein coding gene Chr7:33404062-33409263 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029721
 protein coding gene Chr7:47396729-47402298 (-)
CAST/EiJ ENSTCUG00005043344
 protein coding gene Chr7:37127436-37132620 (-)
CBA/J ENSMUSG00210042833
 protein coding gene Chr7:34515219-34520420 (-)
DBA/2J ENSMUSG00185035748
 protein coding gene Chr7:38390446-38395645 (-)
FVB/NJ ENSMUSG00205031384
 protein coding gene Chr7:34059594-34064796 (-)
JF1/MsJ ENSUMUG00000030306
 protein coding gene Chr7:42870876-42876087 (-)
LP/J ENSMUSG00230050126
 protein coding gene Chr7:43817431-43822632 (-)
NOD/ShiLtJ ENSMUSG00190046803
 protein coding gene Chr7:34387296-34392497 (-)
NZO/HlLtJ ENSMUSG00225014262
 protein coding gene Chr7:42028098-42033299 (-)
PWK/PhJ ENSLUMG00010047725
 protein coding gene Chr7:33349240-33354450 (-)
SPRET/EiJ ENSMSPG00010029832
 protein coding gene Chr7:33118737-33123979 (-)
WSB/EiJ ENSIUOG00005019812
 protein coding gene Chr7:34932489-34937806 (-)



Homology
more
  • Human Ortholog
    BAX, BCL2 associated X, apoptosis regulator
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BAX, BCL2 associated X, apoptosis regulator
  • Synonyms
    BCL2L4
  • Links
    NCBI Gene ID: 581
    UniProt: Q07812

  • Chr Location
    19q13.33; chr19:48954815-48961798 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human BAX associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 4 alleles in 7 genetic backgrounds
    117 phenotypes from multigenic genotypes
    503 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants display hyperplasia of thymocytes and B cells, reproductive failure with abnormal germ cells and gonadal morphology, and reduced cell death in the CNS and PNS. Female mutants exhibit a prolonged ovarian lifespan.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    291
  • GO References
    121
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1048
  • Tissues
    196
  • cDNA Data
    50
  • Literature Summary
    163
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003873 Ensembl Gene Model | MGI Sequence Detail 5202 C57BL/6J ±  kb
    transcript ENSMUST00000033093 Ensembl | MGI Sequence Detail 867 Not Applicable  
    polypeptide ENSMUSP00000033093 Ensembl | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      Genomic 2
      cDNA 50
      Primer pair 24
      Other 4
      Antibodies 23

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16487
    References
    more
    • Summaries
      All 863
      Developmental Gene Expression 163
      Gene Ontology 121
      Phenotypes 503
    • Earliest
      J:19076 Oltvai ZN, et al., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19
    • Latest
      J:391665 Bhatla N, et al., Acute requirement for the hippocampus in putatively conscious vision revealed by a mouse model of blindsight. Curr Biol. 2026 Apr 9;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory