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Lefty2 Gene Detail
Summary
  • Symbol
    Lefty2
  • Name
    left-right determination factor 2
  • Synonyms
    6030463A22Rik, Ebaf, Leftb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443573
    NCBI Gene: 320202
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
  • Regulated by
    Rr179 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr1:180720673-180726668 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 84.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443573
 protein coding gene Chr1:180720673-180726672 (+)
129S1/SvImJ ENSMUSG00200022555
 protein coding gene Chr1:178474563-178480558 (+)
A/J ENSMUSG00195041740
 protein coding gene Chr1:178089988-178096006 (+)
AKR/J ENSMUSG00220019703
 protein coding gene Chr1:177325950-177331928 (+)
BALB/cJ ENSMUSG00180031829
 protein coding gene Chr1:178125790-178131785 (+)
C3H/HeJ ENSMUSG00175035915
 protein coding gene Chr1:178301588-178307583 (+)
C57BL/6NJ ENSMUSG00215018657
 protein coding gene Chr1:177526238-177532233 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014984
 protein coding gene Chr1:170759702-170765907 (+)
CAST/EiJ ENSTCUG00005040617
 protein coding gene Chr1:176051671-176057784 (+)
CBA/J ENSMUSG00210018364
 protein coding gene Chr1:177963172-177969167 (+)
DBA/2J ENSMUSG00185034606
 protein coding gene Chr1:182582590-182588585 (+)
FVB/NJ ENSMUSG00205024811
 protein coding gene Chr1:177021493-177027487 (+)
JF1/MsJ ENSUMUG00000010351
 protein coding gene Chr1:181565945-181571918 (+)
LP/J ENSMUSG00230032041
 protein coding gene Chr1:182140055-182146050 (+)
NOD/ShiLtJ ENSMUSG00190026927
 protein coding gene Chr1:177987434-177993429 (+)
NZO/HlLtJ ENSMUSG00225010286
 protein coding gene Chr1:185893117-185899095 (+)
PWK/PhJ ENSLUMG00010015354
 protein coding gene Chr1:176830345-176836340 (+)
SPRET/EiJ ENSMSPG00010032912
 protein coding gene Chr1:180290846-180296959 (+)
WSB/EiJ ENSIUOG00005011496
 protein coding gene Chr1:177200202-177206197 (+)



Homology
more
  • Human Ortholog
    LEFTY2, left-right determination factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LEFTY2, left-right determination factor 2
  • Synonyms
    EBAF, LEFTA, LEFTYA, TGFB4
  • Links
    NCBI Gene ID: 7044
    UniProt: O00292

  • Chr Location
    1q42.12; chr1:225936598-225941383 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LEFTY2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit embryonic lethality, defects in axial patterning, absent notochord, somites, head folds and heart, and defects yolk sac development. Mice homozygous for another allele exhibit postnatal lethality and left isomerism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    947
  • Tissues
    46
  • cDNA Data
    24
  • Literature Summary
    143
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066652 Ensembl Gene Model | MGI Sequence Detail 5996 C57BL/6J ±  kb
    transcript ENSMUST00000085797 Ensembl | MGI Sequence Detail 2473 Not Applicable  
    polypeptide ENSMUSP00000082952 Ensembl | MGI Sequence Detail 368 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR029034 Cystine-knot cytokine
      IPR003942 Left- Right determination factor
      IPR001111 TGF-beta, propeptide
      IPR017948 Transforming growth factor beta, conserved site
      IPR001839 Transforming growth factor-beta, C-terminal
      IPR015615 Transforming growth factor-beta-like
    • GlyGen
      P57785 1 site
    Molecular
    Reagents
    less
    • All nucleic 68
      Genomic 5
      cDNA 31
      Primer pair 7
      Other 25

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138525
    References
    more
    • Summaries
      All 178
      Developmental Gene Expression 143
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:49270 Meno C, et al., Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Genes Cells. 1997 Aug;2(8):513-24
    • Latest
      J:379628 Yang X, et al., Integrated multi-omic atlas reveals the hierarchy of spatiotemporal regulatory networks of mouse gastrulation. Nat Commun. 2026 Jan 12;17(1):1572
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory